Connexin36 (Cx36) is a new connexin that was recently cloned in mouse, rat and human. It is highly expressed in neurons of the CNS. To gain insight into the transcriptional regulation of this gene, we have cloned the genomic region containing the entire mCx36 gene and sequenced about 7.6kb around the coding region. The computer analysis of this sequence was helpful in defining putative regulati...

A cross sectional study was conducted to assess quality of life (QoL) in patients on maintenance hemodialysis at our centre. QoL was assessed using SF36 questionnairre. Patients who completed 6 months of hemodialysis were included in the study. Various predictors of total score, physical score and mental score were analysed. Secondary outcomes like number of hospitalizations and deaths were als...

We mapped a human deafness locus DFNB36 to chromosome 1p36.3 in two consanguineous families segregating recessively inherited deafness and vestibular areflexia. This phenotype co-segregates with either of two frameshift mutations, 1988delAGAG and 2469delGTCA, in ESPN, which encodes a calcium-insensitive actin-bundling protein called espin. A recessive mutation of ESPN is known to cause hearing ...

BACKGROUND The relationship between socio demographic status and Health Related Quality of Life (HRQOL) has not been well documented in most population of Asian countries including Iran. This study aimed to investigate the determinants of HRQOL in general population living in Bandar Abbas. METHODS This cross sectional study was conducted among general population living in Bandar Abass, Iran f...

BACKGROUND The SF-36 is widely used to assess health-related quality of life (HRQOL), but with few longitudinal studies in healthy populations, it is difficult to quantify its natural history. This is important because any measure of change following an intervention may be confounded by natural changes in HRQOL. This paper assesses mean changes in SF-36 scores over a 3-year period in men and wo...

STUDY OBJECTIVE To assess the representativeness of survey participants by systematically comparing volunteers in a national health and sexuality survey with the Australian population in terms of self reported health status (including the SF-36) and a wide range of demographic characteristics. DESIGN A cross sectional sample of Australian residents were compared with demographic data from the...

INTRODUCTION The Medical Outcomes Study short form 36 health survey (SF-36) is being increasingly used and recommended as a suitable measure of subjective health status. However, it is unlikely that any measure will be appropriate for all groups. We wished to determine the suitability of the SF-36 for assessing quality of life in older stroke patients. METHODS A screening questionnaire was us...

BACKGROUND Health related quality of life (HRQL) is a research topic that has attracted increasing interests around the world over the past two decades. The 36-item Short Form (SF-36) is a commonly used instrument for measuring HRQL. However, the information on Chinese adults' quality of life is limited. This paper reports on the feasibility of using the Mandarin version of SF-36 to evaluate HR...

OBJECTIVE To estimate clinical and social benchmarks for interpretation of score differences on the Short-Form 36 Health Survey, and apply these benchmarks to populations with diabetes mellitus (DM). METHODS Using survival and logistic regression models, we reanalyzed data from three US cohorts: the Medical Outcomes Study (N = 3,445; 541 patients with DM), the Medicare Health Outcomes Survey ...