1Los Alamos National Laboratory, P.O. Box 1663, MS M997, Los Alamos, NM 87545. Email: barrett, marathe, p-tosic @lanl.gov. The work is supported by the U.S. Department of Energy under contract W-7405-ENG-36. 2Department of Computer Science, University at Albany SUNY, Albany, NY 12222. Email: hunt, ravi, djr, res @cs.albany.edu. Supported by a grant from Los Alamos National Laboratory and by NSF...

Web transport systems for transporting films, textile material, paper, etc., are usually large-scale systems. The velocity and the tension of the web are controlled by dividing the systems into several subsystems in which strong coupling exists between the velocity and tension control. A self-tuning PI (STPI) controller with an estimator based on a novel adaptive particle swarm optimization met...

Endoglin (ENG), a co-receptor for several TGFβ-family cytokines, is expressed in dividing endothelial cells alongside ALK1, the ACVRL1 gene product. ENG and ACVRL1 are both required for angiogenesis and mutations in either gene are associated with Hereditary Hemorrhagic Telangectasia, a rare genetic vascular disorder. ENG and ALK1 function in the same genetic pathway but the relative contributi...

The goal of the present study was to evaluate the role of endoglin, a transforming growth factor-beta1 (TGF-beta1) accessory receptor, in the pathogenesis of renal fibrosis. This was achieved by testing a model of tubulo-interstitial fibrosis induced by unilateral ureteral obstruction in endoglin heterozygous (Eng(+/-)) mice. Northern and Western blot analysis revealed that endoglin expression ...

* A preliminary version of this paper appeared in ‘‘Proc. 2nd European Symposium on Ž . Ž . Algorithms ESA’94 pp. 424]435, Springer-Verlag, BerlinrNew York . † 4 E-mail: hunt,ravi,djr,res @cs.albany.edu. ‡ Supported by NSF Grant CCR-89-03319 and CCR-94-06611. § Supported by NSF Grant CCR-90-06396. ¶ E-mail: [email protected]. 5 Part of the work was done when the author was at SUNY, Albany. E-mail...

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BACKGROUND AND PURPOSE Bone marrow-derived cells (BMDCs) home to vascular endothelial growth factor (VEGF)-induced brain angiogenic foci, and VEGF induces cerebrovascular dysplasia in adult endoglin heterozygous (Eng(+/-)) mice. We hypothesized that Eng(+/-) BMDCs cause cerebrovascular dysplasia in the adult mouse after VEGF stimulation. METHODS BM transplantation was performed using adult wi...

OBJECTIVE Hereditary hemorrhagic telangiectasia is a genetic disorder characterized by visceral and mucocutaneous arteriovenous malformations (AVMs). Clinically indistinguishable hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 are caused by mutations in ENG and ALK1, respectively. In this study, we have compared the development of visceral and mucocutaneous A...

Increased levels of soluble endoglin (Sol-Eng) correlate with poor outcome in human cancer. We have previously shown that shedding of membrane endoglin, and concomitant release of Sol-Eng is a late event in chemical mouse skin carcinogenesis associated with the development of undifferentiated spindle cell carcinomas (SpCCs). In this report, we show that mouse skin SpCCs exhibit a high expressio...