BACKGROUND In 2010, the Italian Ministry of Health decided to start the planning process to elaborate the National Plan of Prevention 2010-2012 jointly with the 21 Regions. The National Institute of Health was responsible for supporting regional planners (RPs) by an original participatory approach of a web-based Community of Practice (CoP) to set up their own Regional Plans of Prevention. In th...

Background Rheumatic disesases may involve multiple systems and chronic kidney disease (CKD) can be seen during the course of diseases. Accompanying CKD affects choice treatments in patients with rheumatic disease. There is limited data on use biological DMARDs Objectives To determine preferred first second bDMARDs bDMARD cohort. Methods The Hacettepe University database (HUR-BIO), was establis...

Background: Aberrant activation of B cells and autoantibody mediated tissue damage are hallmarks autoimmune diseases such as systemic lupus erythematosus (SLE) rheumatoid arthritis (RA). Therefore, novel treatments that prevent generation or antibody-mediated end organ high interest. Bruton’s tyrosine kinase (BTK) transduces signals downstream the cell receptor (BCR), toll-like receptors, Fc re...

Background: Venous thromboembolism is a leading cause of morbidity and mortality in the United States. Accurate and timely diagnosis may be confounded by its nonspecific clinical presentation. Wells Criteria is a reliable screening tool with high sensitivity; however, recent data suggest that D-dimer is increasingly used as a primary screening test. While the sensitivity of D-dimer is comparabl...

Escherichia coli’s cAMP receptor protein (CRP), the archetypal bacterial transcription factor, regulates over a hundred promoters by binding 22 bp symmetrical sites with the consensus core half-site TGTGA. However, Haemophilus influenzae has two types of CRP sites, one like E.coli’s and one with the core sequence TGCGA that regulates genes required for DNA uptake (natural competence). Only the ...

Breast cancer is the most prevalent in Indonesia, 19.2% out of all cancers [1]. In 1992, breast patients (60-70%) sought medical treatment when were late stages (stage III and IV) [2]. Thirty years later data collected from several teaching hospitals Indonesia shows that 68- 73% come to centers [3,4,5]. It interesting learn why number late-stage remains same despite advancement early detection ...

Chronic periodontitis is an infectious disease characterized by the accumulation of inflammatory cells in extravascular gingival connective tissue, which finally causes the breakdown of periodontal tissue and tooth loss (21, 28, 35, 36, 38). Treponema denticola has been identified as a major pathogen in human periodontal disease (1, 18, 20, 25). Previous studies have revealed that a number of i...

We report the results of an integrated modeling and in situ isotope tracer experiment study examining the fate of bacterial carbon in an intertidal sediment. 13C-glucose was injected into the upper 10 cm of an intertidal sediment, which successfully tagged the bacterial community as evidenced by 13C enrichment of bacterial specific polar-lipid-derived fatty acids. Over a period of 4.5 months, 1...

RESUMEN El presente trabajo muestra como una comunidad Shuar, ubicada al sur del Ecuador, se involucra y participa en el diseño de un proyecto ecoturístico partiendo modelo Turismo Basado la Comunidad [TBC], aras mejorar sus condiciones socioeconómicas, utilizando metodologías técnicas cualitativas como: talleres participativos e interactivos, observación levantamiento información in situ entre...

Transplant glomerulopathy is established as a hallmark of chronic antibody-mediated rejection in kidney transplant patients with donor-specific HLA antibodies (HLA-DSA). The clinical importance the absence HLA-DSA not well established. To help define this, 954 (encompassing 3744 biopsies) who underwent transplantation 2004-2013 were studied retrospective high-resolution genotyping both donors a...