Objective: The objective of the reported study was to develop new chemical entities as potential anti-inflammatory agents with analgesic and nitric oxide releasing properties. Methods: The compounds were designed with the help of docking studies. In the synthetic study the target compounds were obtained by reacting 2(substituted-2,5-diphenyl-oxazole)-acetic acid (2a-2v) with nitro-oxy ethyl bro...

BACKGROUND Expectations held by health professionals and their patients are likely to affect treatment choices in subacute inpatient rehabilitation settings for older adults. There is a scarcity of empirical evidence evaluating whether health professionals expectations of the quality of their patients' future health states are accurate. METHODS A prospective longitudinal cohort investigation ...

We investigate a lattice construction method for the Coppersmith technique for finding small solu-tions of a modular equation. We consider its variant for simultaneous equations and propose a methodto construct a lattice by combining lattices for solving single equations. As applications, we consider(i) a new RSA cryptanalysis for multiple short secret exponents, (ii) its partial ke...

To examine real-world treatment patterns, healthcare resource utilization and costs among third-line (3L) relapsed refractory (R/R) diffuse large B-cell lymphoma (DLBCL) patients in the United States. A retrospective claims analysis was carried out using IBM® MarketScan® Database (Jan 2015-Dec 2019) to assess patterns adult DLBCL receiving 3L treatment. diagnosis of (ICD10 C83.X), ≥ 12 months p...

BACKGROUND Patient-reported health-related quality of life is an important outcome measure when assessing the quality of hip fracture surgery. The frequently used EQ-5D index score has unfortunately important limitations. One alternative can be to assess the distribution of each of the five dimensions of the patients' descriptive health profile. The objective of this paper was to investigate he...

Implicit polynomial 2D curves and 3D surfaces are potentially among the most useful object or data representations for use in computer vision and image analysis. That is because of their interpolation property, Euclidean and aane invariants, and Bayesian recog-nizers. This paper studys and compares various tting algorithms in a uniied framework of stability analysis. It presents a new robust 3L...

Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity against C.albicans, C.glabrata, C.krusei, and C.parapsilopsis. The structures of the newly synthesized compounds 3a-3l were confirmed by IR, ¹H-NMR, 13C-NMR, and ESI-MS spec...

DNA methyltransferase (DNMT) 1 and 3 are primarily responsible for abnormal methylation in cancer. Unlike these DNMTs, DNA methyltransferase 3-like (DNMT3L) harbors no conserved catalytic domain, and has been shown to function as a regulatory cofactor for DNA methylation. However, it is unclear whether DNMT3L directly regulates DNA methylation in cancer cells. To address this, we investigated t...

In Spain, new generation ALK inhibitors have been added as therapeutic options, with specific indications, to those already available for advanced or metastatic ALK-positive non-small cell lung cancer (mNSCLC ALK+). this context it is key understand current treatment management of subpopulation by line in clinical practice, well the most prescribed sequences, cases they not fully established. T...

BACKGROUND Existing evidence for validity of the visual analog scale of the EQ-5D-3L questionnaire (EQ-VAS) is weak in Chinese-speaking respondents in Singapore. We therefore investigated the validity of the Chinese (Singapore) version of EQ-VAS in patients with diabetes. METHODS In a cross-sectional survey, patients with type 2 diabetes seen in a primary care facility completed an identical ...