In the present work two new analytical methods, a gravimetric and a spectrophotometric, for the assay of piperazine free base and its soluble salts in the anthelmitic preparation "Oxyuran", are described. Both approaches are based on the quantitative reaction between the diprotonated cationic form of piperazine and the 3-methyl-4-nitro-1-p-nitrophenyl-5-pyrazolone (picrolonic acid), in sulfuric...

Two new cobaltous-porphyrin complexes, namely (?-piperazine)-bis[(meso-tetra(para-methoxyphenyl)porphyrinato)]cobalt(II) and (piperazine)[meso-tetra(para-chlorophenyl)porphyrin]cobalt(II) dichloromethane disolvate, with the formulas [{CoII(TMPP)}2(?2-pipz)] (complex 1) [CoII(TClPP)(pipz)]·2CH2Cl2 2), were used efficiently as catalysts in degradation of 4-nitrophenol (4-NP) an aqueous hydrogen p...

Piperazine is widely used as an intermediate in the manufacture of insecticides, rubber chemicals, corrosion inhibitors, and urethane. In this study, a highly effective piperazine-degrading bacteria strain, TOH, was isolated from the acclimated activated sludge of a pharmaceutical plant. This strain, identified as Paracoccus sp., utilises piperazine as the sole source of carbon, nitrogen and en...

Some inverse agonists of cannabinoid receptor type 1 (CB1) have been demonstrated to be anorectic antiobesity drug candidates. However, the first generation of CB1 inverse agonists, represented by rimonabant (SR141716A), otenabant, and taranabant, are centrally active, with a high level of psychiatric side effects. Hence, the discovery of CB1 inverse agonists with a chemical scaffold distinct f...

In this study, the indoloquinoline backbone and piperazine were combined to prepare indoloquinoline-piperazine hybrids and their ruthenium- and osmium-arene complexes in an effort to generate novel antitumor agents with improved aqueous solubility. In addition, the position of the metal-binding unit was varied, and the effect of these structural alterations on the aqueous solubility and antipro...

THE TITLE COMPOUND (SYSTEMATIC NAME 4-{3-[2-aza-tricyclo-[9.4.0.0(3,8)]penta-deca-1(15),3,5,7,11,13-hexaen-2-yl]prop-yl}-1-(2-hy-droxy-eth-yl)piperazine-1,4-diium dichloride), C(23)H(31)N(3)O(+)·2Cl(-), is the dihydro-chloride of a piperazine derivative bearing a bulky 3-(5H-dibenz[b,f]azepin-5-yl)propyl substituent. Protonation took place on both N atoms of the piperazine unit. The diaza-cyclo...