BACKGROUND AND PURPOSE Perihematomal edema formation and consequent cell death contribute to the delayed brain injury evoked by intracerebral hemorrhage (ICH). We aimed to evaluate the effect of α7 nicotinic acetylcholine receptor (α7nAChR) stimulation on behavior, brain edema, and neuronal apoptosis. Furthermore, we aimed to determine the role of the proapoptotic glycogen synthase kinase-3β (G...

BACKGROUND Ataxia-telangiectasia (A-T) is a devastating human autosomal recessive disorder that causes progressive cerebellar ataxia, immunodeficiency, premature aging, chromosomal instability and increased cancer risk. Affected patients show growth failure, poor weight gain, low body mass index (BMI), myopenia and increased fatigue during adolescence. The prevalence of alterations in body comp...

Rice bean (Vigna umbellata) is one of the under-utilized crops which can become a promising pulse crop. A field experiment was conducted during kharif season 2020 at Research Farm, College Agriculture, Central Agricultural University, Imphal, Manipur to study effect planting geometry and nutrient management on yield, economics quality dwarf rice under rainfed condition. The laid out in Factoria...

To investigate the response of rainfed maize to sowing methods and NPK levels, an experiment was undertaken during kharif of 2011 and 2012 at Dryland (Kerawa) Agriculture Research Station, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Budgam. The experiment was laid out in a randomized block design with combination of 2 sowing methods (flat sowing, 75 cm apart ro...

Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated. Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for ...

Fodder yield and quality must be improved for sustainable livestock production. A lack of or low application phosphorus (P) potassium are among the leading constraints lower fodder sorghum [most cultivated crop during kharif season (crop cultivation in summer harvesting winter] Aridisol Pakistan. Therefore, this two-year field study evaluated role different P K levels on cultivar ‘Ijar-2002’ pl...

Article history: Received 2 February 2016 Received in revised form 24 May 2016 Accepted 5 June 2016 Available online 11 June 2016 Classical molecular dynamics (MD) simulations were used to study the structural changes in the surfaces of biocompatible phosphate glasseswith compositions (P2O5)0.45(CaO)x(Na2O)0.55−x (x=30, 35, 40) to evaluate their effect on the solubility of the material. Direct ...

Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated. Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for...

K-ras is the most frequently mutated oncogene in non-small cell lung cancer (NSCLC), the most common form of lung cancer. Recent studies indicate that NSCLC patients with mutant K-ras do not respond to epidermal growth factor receptor inhibitors. In the attempt to find alternative therapeutic regimes for such patients, we tested PHA-848125, an oral pan cyclin-dependent kinase inhibitor currentl...

During the kharif season of 2020-22, a field experiment with soybean in soybean-wheat cropping system was conducted at ICAR-Indian Institute Soil Science, Bhopal, (M.P.) to assess effect different levels crop residue retention treatments and nutrient doses on growth parameters, physiological indices, yield attributes, profitability soybean. The laid out Factorial Randomized Block Design (FRBD) ...