BACKGROUND Boron is a bioactive element that satisfies several of the criteria for essentiality in humans. OBJECTIVE The objective was to establish the profile of boron metabolism in human milk. DESIGN Lactating mothers of premature (PRT; n = 10, <2000 g birth weight, <37 wk gestation) and full-term (FT; n = 10, >2500 g, 39-41 wk gestation) infants living in St John's, Canada, collected mil...

BACKGROUND Although chronic cough is a common problem in clinical practice, data on the prevalence and characteristics of cough in the general population are scarce. Our aim was to determine the prevalence of chronic cough that is not associated with diagnosed respiratory conditions and examine the impact on health status and psychological health, in a representative adult population cohort M...

The association between exposure to environmental tobacco smoke and lung cancer in female lifetime nonsmokers was evaluated using data colleded during the first 3 years of an ongoing case-control study. This large, multicenter, population-based study was designed to minimize some of the methodological problems which have been of concern in previous studies of environmental tobacco smoke and lun...

BACKGROUND Recommended management of attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) includes therapy with exogenous C1INH. Thrombotic/thromboembolic events (TEE) have been reported with plasma-derived C1INH, but so far none with recombinant human C1INH (rhC1INH). This phase III, randomized, placebo (saline)-controlled study evaluated the saf...

Fedarko, N.S., Jain, A., Karadag, A., Van Eman, M.R. & Fisher, L.W. (2001) Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. Clinical Cancer Research, 7, 4060– 4066. Flamant, S., Kortulewski, T., Dugray, A., Bonnet, M.L., Guillier, M., Guilhot, F., Bourhis, J.H., Vainchenker, W., Roux, D.T.L. & Turhan, A.G. (2005) Osteopontin is upregulated by BCR-ABL...

BACKGROUND There are two approaches to the treatment of atrial fibrillation: one is cardioversion and treatment with antiarrhythmic drugs to maintain sinus rhythm, and the other is the use of rate-controlling drugs, allowing atrial fibrillation to persist. In both approaches, the use of anticoagulant drugs is recommended. METHODS We conducted a randomized, multicenter comparison of these two ...