The present work was conducted as part of a larger America Makes funded project to begin to examine the effects of changes in process variables on the resulting microstructure and fracture and fatigue behavior of as-deposited Ti-6Al-4V. In addition to presenting initial results on process mapping of the electron beam powder bed process, the present work also documents the location-dependent pro...

Quantification of the cerebrospinal fluid (CSF) system may be useful for distinguishing relative treatments in the presence of choroid plexus papillomas (CPPs). To study the CSF system, mathematical models and simulations detailing the cerebral blood flow and CSF filtration were constructed to represent a normal brain, a brain with CPP located in the left lateral ventricle, and a brain with CPP...

The microstructure and mechanical behavior of simple product geometries produced by layered manufacturing using the electron beam melting (EBM) process and the selective laser melting (SLM) process are compared with those characteristic of conventional wrought and cast products of Ti-6Al-4V. Microstructures are characterized utilizing optical metallography (OM), scanning electron microscopy (SE...

The diamond-like carbon (DLC) films deposited on the articulating surface of medical-grade Ti and Ti–6Al–4V were characterized. The DLC films were synthesized by r.f. plasma assisted chemical vapor deposition (PACVD) using C6H6 at 10 mTorr. For wear tests, the ball-ondisk type wear tester was employed by wearing a 5-mm diameter ruby ball against a rotating metal disk. The DLC coating dramatical...

This paperpresentsexperimental investigationsandfinite element simulationsonmicro-millingofTi–6Al– 4V alloy with fine grain uncoated and cBN coated micro-end mills. Micro-milling of Ti–6Al–4V using uncoated and cBN coated tungsten carbide micro-end mills are conducted; surface roughness, burr formation and tool wear are measured. Effects of machining parameters on surface roughness, burr format...

The electrochemical behaviour of the biomedical and metallic alloys, especially in the orthopaedic implants fields, raises many questions. This study is dedicated for studying the Ti6Al-4V alloy, by electrochemical impedance spectroscopy, EIS, in various physiological media,: Ringer solution, phosphate buffered solution (PBS), PBS solution and albumin, PBS solution with calf serum and PBS solut...

This paper studied the cutting properties of Ti-6Al-4V under cryogenic cooling to find a solution of improvement in tool load-carrying, thermal stress, tool life and finish quality. Firstly, this paper established a 3-D cutting model of Ti-6Al-4V under cryogenic cooling with liquid nitrogen, and then set the parameters of material, friction model and cutting conditions. Based on this model, the...

In this paper, a nanocrystalline surface layer without impurities was fabricated on Ti-6Al-4V alloy by means of surface mechanical attrition treatment (SMAT). The grain size in the nanocrystalline layer is about 10 nm and grain morphology displays a random crystallographic orientation distribution. Subsequently, the low-temperature boriding behaviors (at 600 °C) of the SMAT sample, including th...

CD44 is a ubiquitous surface molecule that exists as a number of isoforms, generated by alternative splicing of 10 "variant" exons. Little is known about the expression and function of the variant isoforms, except that certain isoforms may play a role in cancer metastasis. We produced mAbs against CD44 variant regions encoded by exons 4v, 6v, and 9v, by immunizing mice with a fusion protein spa...

Fiber reinforced metal composites were fabricated by diffusion welding. The matrices used were commercially pure titanium (CPTi) and two kinds of titanium alloys (Ti-6A1-4V and Ti-21V-4A1), and the filaments were two kinds of SiC-CVD fiber. The structure and the distribution of elements in reaction zone between matrix and filament both in as-fabricated state and in heat-treated state were inves...