In the current work, a ligand N'1-((E)-2-hydroxy-3H-indol-3-ylidene)-N'3-((E)-2-oxoindolin-3-ylidene)malonohydrazide (H4MDI) and its chelates [Cr2(H2MDI)(H2O)2Cl4] [Ni2(MDI)(H2O)6].4H2O have been isolated characterized using different physico?chemical methods, as infrared (IR), thermogravimetric analysis (TGA) differential thermogravimetry (DTG) in solid state, 1H?NMR, 13C?NMR UV/visible soluti...

INTRODUCTION In an African setting surgery is generally accepted as the treatment of first choice for glaucoma. A problem with trabeculectomy surgery for the glaucomas is the frequent co-existence and exacerbation of cataract. We report a randomized controlled trial to compare the use of beta radiation with 5FU in combined cataract and glaucoma surgery. PARTICIPANTS AND METHODS Consenting adu...

The result with radiotherapy alone in patients with locally advanced nasopharyngeal carcinoma (NPC) was disappointing. Encouraging results have been reported with the use of concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck. Hence, we decided to explore the use of this treatment schedule in patients who presented with locally advanced di...

Colorectal cancer (CRC) which affects over one million individuals annually [1] has recently seen an increased interest in identifying biomarkers and new treatment strategies. This has resulted in a significant rise in the median overall survival of CRC from 6 to 24 months [2]. Standard treatment for CRC has progressed from 5-fluroruracil monotherapy to combination chemotherapy (5-flurouracil a...

CONTEXT Pancreatic metastasis from colorectal malignancy is rare and accounts for less than 2% of all pancreatic metastases. A case of colonic metastasis to the pancreas is reported and the literature is reviewed to assess the role and outcome of pancreatic resection for metastatic tumors from colorectal malignancy. CASE REPORT A 58-year-old female underwent an emergency left hemicolectomy fo...

PURPOSE The success of enzyme/prodrug cancer therapy is limited by the uncertainty in the delivery of the enzyme in vivo. This study shows the use of noninvasive magnetic resonance (MR) and optical imaging to image the delivery of a prodrug enzyme. With this capability, prodrug administration can be timed so that the enzyme concentration is high in the tumor and low in systemic circulation and ...

E xtracorporeal life support has evolved to become a viable support option in patients with acute cardiac failure. Tailored mechanical circulatory support (MCS) can now be provided to patients using existing extracorporeal life support devices. 1 We report the successful use of peripheral venoarte-rial extracorporeal membrane oxygenation (ECMO) to provide MCS to a patient with acute 5-flurourac...

This review will be concerned primarily with a practical yet comprehensive diagnostic procedure for the diagnosis or even mass screening of a variety of metabolic disorders. This rapid, highly sensitive procedure offers possibilities for clinical chemistry laboratories to extend their diagnostic capacity to new areas of metabolic disorders. The diagnostic procedure consists of the use of urine ...

BACKGROUND The impact of bevacizumab on functional recovery and histology of the liver was evaluated in patients undergoing hepatic resection for colorectal liver metastases (CLM) following bevacizumab treatment. METHODS Consecutive patients who had resection of CLM between July 2005 and July 2009 following preoperative chemotherapy were identified retrospectively from a prospectively collect...

INTRODUCTION Breast cancer is increasingly regarded as a heterogeneous disease which can be classified into distinct molecular subtypes with prognostic significance. MATERIALS AND METHODS ER, PR, HER2 and ki-67 were used to divided 102 breast cancers treated with neoadjuvant chemotherapy (NCT) into 4 subtypes: luminal A (ER+, PR+, HER2-, and ki-67≤14%), luminal B (ER+, PR+, HER2- and ki-67>14...