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This report summarizes the proceedings of the 6th and 7th workshops of the Genomic Standards Consortium (GSC), held back-to-back in 2008. GSC 6 focused on furthering the activities of GSC working groups, GSC 7 focused on outreach to the wider community. GSC 6 was held October 10-14, 2008 at the European Bioinformatics Institute, Cambridge, United Kingdom and included a two-day workshop focused ...

Background ‘Mitochondrial Myopathy’ (MM) refers to genetically-confirmed Primary Mitochondrial Disease (PMD) that predominantly impairs skeletal muscle function. Validated outcome measures encompassing core MM domains of weakness, fatigue, imbalance, impaired dexterity, and exercise intolerance do not exist. The goal this study was validate clinically-meaningful, quantitative specific MM. Metho...

The octyl alcohol, DL-2-ethyl-fl-hexanol, is used industrially as a solvent and, in the form of the ester, di-2-ethylhexyl phthalate, as a plasticizer. According to Shaffer, Carpenter & Smyth (1945) this ester is saponified in rats and rabbits, phthalic acid being excreted and there being also an increase in the short-chain fatty acids in the urine. After feeding the DL-alcohol to rabbits, Akiy...

grinoides ranges from the Canary Islands eastwards across some areas of North Africa, the Middle East and some parts of central Asia (Fergusson-Lees and Christie, 2002). It has characteristic plumage patterns and morphometric differences with respect to the rest of peregrine subspecies, but genetic variation is quite low in the peregrinus/pelegrinoides group, and it could be treated as a subspe...

53 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 216 No. 1 53–63 https://doi.org/10.1083/jcb.20161001

Soluble guanylate cyclases (sGCs) function as heme sensors that selectively bind nitric oxide (NO), triggering reactions essential to animal physiology. Recent discoveries place sGCs in the H-NOX family (heme nitric oxide/oxygen-binding domain), which includes bacterial proteins from aerobic and anaerobic organisms. Some H-NOX proteins tightly bind oxygen (O2), whereas others show no measurable...

Background and Aims. There is no consensus so far regarding the optimal endoscopic method for treatment of small rectal neuroendocrine tumor (NET). The aim of this study was to compare treatment efficacy, safety, and procedure time between endoscopic submucosal resection with band ligation (ESMR-L) and endoscopic submucosal dissection (ESD). Methods. We conducted a prospective study of patients...