OBJECTIVE Regarding vulvar cancer, a nomogram has been suggested for the prediction of relapse-free survival (RFS). While the nomogram has been developed and validated in a Western study, there was no validation in Korean population. Thus, we have undertaken the study to assess the applicability of nomogram for predicting RFS in Korean patients with vulvar cancer. METHODS A total of 204 cases...

AIM: To elucidate the safety and visual quality of implantable collamer lens with central hole (ICL V4c) implantation for correcting moderate high myopia at least 5y. METHODS: This retrospective study was conducted on 58 patients (114 eyes) who were followed up 5y after ICL V4c implantation. The observation done before 1d, 1mo, 1 or more surgical procedure. acuity, subjective refraction, intrao...

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bcl-x is a member of the bcl-2 family of genes and by alternative splicing gives rise to two distinct mRNAs: bcl-xL and bcl-xS. We have previously investigated the expression of Bcl-x in neuroblastoma (NB) cell lines and have shown that Bcl-xL is expressed and functions to inhibit chemotherapy-induced apoptosis. However, none of the NB cell lines expressed Bcl-xS. The aim of the present study w...

BACKGROUND Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson's disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumin (DMC), a derivative of curcumin against rotenone induced neurotoxicity. METHODS SH-SY5Y neuroblastoma ...

The hill tribes in Thailand traditionally depend on rotational shifting cultivation (RSC). However, insufficient understanding remains post-fire soil properties and erodibility ( k -values) with fallow years. To address this gap, the levels of organic carbon (SOC), total nitrogen (STN), nutrients, after fire RSC were investigated. Topsoil (0–10 cm) samples from sites 4 (RSC-4Y), 5 (RSC-5Y), 7 (...

Abstract Objectives The current research examines the protective effects of Piper cubeba ethanolic extract and its isolated lignans; Cubebin Hinokinin fractions against Alzheimer’s Disease (AD) in vitro model. Methods Dried powdered fruit P. were extracted ethanol fractionated using silica gel column chromatography. Of 15 eluted fractions, two indicated presence targeted Lignans; Cubebin. They ...

INTRODUCTION CD3+ γδ+ T cells comprise 2% to 5% of circulating T cells with Vγ9Vδ2+ cells the dominant circulating subtype. Vγ9Vδ2+ cells recognize non-peptide phosphoantigens and stress-associated NKG2D ligands expressed on malignant cells. Strategies that incorporate the tumoricidal properties of γδ T cells represent a promising immunotherapeutic strategy for treatment of solid malignancies i...

Thimerosal (ethylmercurithiosalicylic acid), an ethylmercury (EtHg)-releasing compound (49.55% mercury (Hg)), was used in a range of medical products for more than 70 years. Of particular recent concern, routine administering of Thimerosal-containing biologics/childhood vaccines have become significant sources of Hg exposure for some fetuses/infants. This study was undertaken to investigate cel...

The dynamic regulation of transcriptional events is fundamental to many aspects of neuronal cell functions. However, proteomics methods have not been routinely used in global neuroproteomics analyses of transcriptional regulators because they are much less abundant than the "house-keeping" proteins in cells and tissues. Recent improvements in both biochemical preparations of nuclear proteins an...