A series of chiral linear and macrocyclic bridged pyridines has been prepared starting from pyridine-2,6-dicarbonyl dichloride (2). The coupling of 1 with D-alanyl methyl ester gave 2,6-bis-D-alanyl pyridine methyl ester (3). Hydrazinolysis of 3 with hydrazine hydrate afforded bis-hydrazide 4. The latter was reacted with thiophene-2-carbaldehyde, phthalic anhydride or cyclohexanone to afford bi...

The title compounds were prepared by reaction of 1,1'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)diethanone (1) with different aromatic aldehydes 2a-c, namely Furfural (2a), 4-chlorobenzaldehyde (2b) and 4-methoxybenzaldhyde (2c) to yield the corresponding α,β-unsaturated ketones 3a-c. Compound 3 was reacted with malononitrile, 2-cyanoacetamide or 2-cyanothioacetamide yielded the corresponding ...

The synthesis of polyethynyl aromatics as starting materials for the preparation of highly cross-linked organic solids containing high atom fractions of carbon is described. Treatment of bromoand iodoaromatic compounds with (trimethylsily1)acetylene (TMSA) in the presence of palladium(0) and copper(1) in amine solvents yields (trimethylsily1)ethynyl-substituted aromatics. The TMS protecting gro...

The homodinuclear complexes [Ni(RNPyS4)]2 (; RNPyS4 = 2,6-bis(2-mercaptophenylthiomethyl)-4-R-pyridine; R = H, MeO, Cl, Br, i-Pr) were found to be prepared by reactions of the in situ generated Li2[Ni(1,2-S2C6H4)2] with 2,6-bis[(tosyloxy)methyl]pyridine and its substituted derivatives 2,6-bis[(tosyloxy)methyl]-4-R-pyridine. Further reactions of with Fe3(CO)12 gave both heterotrinuclear complexe...

Lithium compounds of tetradentate amino-bis(phenolato)-tetrahydrofuranyl ligands, Li(2)[L1] (1) and Li(2)[L2] (2) (where [L1] = 2-tetrahydrofuranyl-N,N-bis(2-methylene-4-methyl-6-tert-butylphenolate), and [L2] = 2-tetrahydrofuranyl-N,N-bis(2-methylene-4,6-tert-butylphenolate)) were characterized by multinuclear solution NMR and solid-state (6)Li and (7)Li NMR spectroscopy. The proligands, n-pro...

the synthesis of the title compound is described. this compound was found to be active (3c) against a number of pathogenic microorganisms in vitro. it is a non-absorbable antibacterial topically and its pharmacologic studies revealed that it is a non-toxic agent with a wide range of safety. it proved to be effective in the prevention and treatment of pseudomonaswound infections in volunteer pat...