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 Purpose: To determine the effect of glutathione (GSH) suppressors styrene oxide (SO) and diethyl maleate (DEM) on hepatic expression cytochrome P450 family 1 (Cyp1) isoforms that are related to carcinogenesis including Cyp1a1, Cyp1a2, Cyp1b1.
 Methods: Seven-week-old ICR mice were intraperitoneally injected with SO (150 300 mg/kg/day), DEM (175 350 or N-acetylcysteine (NAC; 600 mg/k...
BACKGROUND Combined pegylated interferon and ribavirin has improved chronic hepatitis C (CH-C) therapy; however, sustained virological response is achieved in only about half of the patients with a 1b genotype infection. We assessed oral ursodeoxycholic acid (UDCA) on serum biomarkers as a possible treatment for interferon non-responders. METHODS CH-C patients with elevated alanine aminotrans...
background: furazolidone has been used as an alternative for clarithromycin or metronidazole in helicobacterpylori ( h . pylori ) eradication regimens. in iran, 14-day furazolidone-containing quadruple regimens have shown promising eradication rates, but short-course, low dose therapies are always attractive. therefore, we designed a study to compare the efficacy of two 10-day triple regimens ...
Flavonols, flavanones and flavones (FLAV) are sub-classes of flavonoids that exert cardioprotective and anti-carcinogenic properties in vitro and in vivo. We aimed to estimate the FLAV dietary intake, their food sources and associated lifestyle factors in ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. FLAV intake and their ...
Gabapentin enacarbil is a prodrug of the anticonvulsant gabapentin. The efficacy and safety of gabapentin enacarbil for the treatment of moderate to severe primary restless legs syndrome (RLS) has been evaluated in several clinical trials in the United States and Japan. Although most clinical trials assessed gabapentin enacarbil at doses greater than 600 mg/day and demonstrated the overall safe...
Owing to importance of employing native and traditional medicinal plants with good efficacy against malaria parasites, an ethanolic extract of Peganum harmala L. was tested on Plasmodium berghei in sourian mice and a comparison was made with the effect of chloroquine on the same parasite. In this study 56 sourian mice were divided into 8 groups, each consisting of seven animals. The first 7 gro...
OBJECTIVES The purpose of this study was to investigate the efficacy of tylvalosin (Aivlosin Water Soluble Granules, ECO Animal Health) in drinking water for control of Mycoplasma hyopneumoniae (M hyo) on a farm with chronic enzootic pneumonia (EP) problems and high prevalence of mycoplasma-like lesions at slaughter. DESIGN On a 4000-sow farm in the southeast of Spain, 1500 animals of same ag...
BACKGROUND Imatinib dose escalation is advocated for gastrointestinal stromal tumour (GIST) treatment, but its effectiveness compared with sunitinib and best supportive care (BSC) after failure at the 400 mg/day dose is unknown. OBJECTIVES To assess the effectiveness and cost-effectiveness of imatinib at escalated doses of 600 or 800 mg/day for patients with unresectable and/or metastatic GIS...
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