Sodium channel Na(V)1.7, encoded by the SCN9A gene, is preferentially expressed in nociceptive primary sensory neurons, where it amplifies small depolarizations. In studies on a family with inherited erythromelalgia associated with Na(V)1.7 gain-of-function mutation A863P, we identified a nonsynonymous single-nucleotide polymorphism within SCN9A in the affected proband and several unaffected fa...

The objective of the article was to assess therapeutic linear accelerator performance. Material & method used were quality control tools, direct measurement & theoretical calculation methods. The analysis of results showed that: shift of machine isocenter was 1 mm then increases up to 2 mm through the gantry angles 0 to 300° and 300 to 360 respectively. The diaphragm rotation isocenter clock & ...

Dose inhomogeneity in treatment planning can be compensated using physical wedges. Enhanced dynamic wedges (EDW) were introduced by Varian to overcome some of the shortcomings of physical wedges. The objectives of this study were to measure EDW output factors for 6 MV and 20 MV photon energies for a Varian 2300CD. Secondly, to review the literature in terms of published enhanced dynamic wedge o...

Abstract Background Nearly all meningiomas express somatostatin receptor 1/2 (SSTR1/SSTR2); therefore, SSTR ligands such as 68Ga-DOTATATE can be utilized for meningioma radiotherapy treatment planning. Incorporation of PET assists with target delineation and may reduce the dose to organs-at-risk (OARs). We hypothesize that PET-based plans will OARs when compared MRI-based plans. METHODS All wer...

Introduction: Physical wedge as a useful tool has been utilized in radiotherapy to modify photon beam shape and intensity such that it distributes dose uniformly in tumor site and reduces hot points. Since during Linac commissioning dosimetric parameters like output factors and lateral dose profiles are measured only for symmetric open and wedged fields, so calculation the par...

Purpose To implement an in-house developed position monitoring software, SeedTracker, for conventional fractionation prostate radiotherapy, and study the effect on dosimetric impact intrafraction motion. Methods Thirty definitive radiotherapy patients with implanted fiducial markers were included in study. All treated VMAT technique plans generated using Pinnacle planning system 6MV beam model ...

background: megavoltage beams used in radiotherapy are contaminated with secondary electrons. different parts of linac head and air above patient act as a source of this contamination. this contamination can increase damage to skin and subcutaneous tissue during radiotherapy.  monte carlo simulation is an accurate method for dose calculation in medical dosimetry and has an important role in opt...

radiotherapy plays an essential role in the management of breast cancer. three-dimensional conformal radiation therapy (3d-crt) is applied based on 3d image information of anatomy of patients. in three-dimensional conformal radiation therapy (3d-crt) for breast cancer one of the common techniques is tangential technique. in this project, various parameters of tangential and supraclavicular fiel...