نتایج جستجو برای: 7 و mda
تعداد نتایج: 1358944 فیلتر نتایج به سال:
Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a novel cytokine displaying selective apoptosis-inducing activity in transformed cells without harming normal cells. The present studies focused on defining the mechanism(s) by which a GST-MDA-7 fusion protein inhibits cell survival of primary human glioma cells in vitro. GST-MDA-7 killed glioma cells with diverse geneti...
Characterizing genes associated with leukemic cell differentiation may provide help for understanding mechanisms on the leukemia differentiation. The aim of this study is to investigate whether the expression of melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) could be induced during leukemia differentiation and whether mda-7/IL-24 plays a role in leukemia differentiation...
OBJECTIVE To explore the relationship between minimal disease activity (MDA) and the low disease activity cutoffs of the Psoriatic ArthritiS Disease Activity Score (PASDAS) and the Composite Psoriatic Disease Activity Index (CPDAI). METHODS Data from the GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) composite exercise (GRACE) study were used for these analyse...
The melanoma differentiation associated gene-7 (mda-7), also known as interleukin-24 (IL-24) is a novel cytokine, which exhibits both tumor suppressing and immunostimulatory activities. Mda-7 has the ability to restrain growth and induce programmed cell death (apoptosis) in a wide variety of human cancer cells without having similar effects on normal cells. This study was performed to investiga...
ةصلاخلا Allopeas gracilis is recorded for the first time in southern Iraq. It was collected from two localities (Abu-Al Khaseeb region and Hareer region) from Basrah city. ضرلاا عقوقلا نم ةنيع نورشعو نامث ي Allopeas gracilis مت للاخ ةرصبلا ةنيدم ،ريرح ةقطنم و بيصخلا وبا ةقطنم نم اھعمج ناسين رھش 2008 راذاو 2008 يلاوتلا ىلع . ليجستلا اذھ ربتعي دعب ةرصبلا ةنيدم نم ةيضرلاا عقاوقلا نم ثلاثلا Monacha...
Pancreatic cancer is an aggressive disease with limited therapeutic options. Melanoma differentiation–associated gene-7/ interleukin-24 (mda-7/IL-24), a potent antitumor cytokine, shows cancer-specific toxicity in a vast array of human cancers, inducing endoplasmic reticulum stress and apoptosis, toxic autophagy, an antitumor immune response, an antiangiogenic effect, and a significant “bystand...
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) encodes a tumor suppressor gene implicated in the growth of various tumor types including breast cancer. We previously demonstrated that recombinant adenovirus-mediated mda-7/IL-24 expression in the mammary glands of carcinogen-treated (methylnitrosourea, MNU) rats suppressed mammary tumor development. Since most MNU-induce...
Limited options are available for treating patients with advanced prostate cancer (PC). Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), an IL-10 family cytokine, exhibits pleiotropic anticancer activities without adversely affecting normal cells. We previously demonstrated that suppression of the prosurvival Bcl-2 family member, myeloid cell leukemia-1 (Mcl-1), is requi...
Terminal prostate cancer is refractory to conventional anticancer treatments because of frequent overexpression of antiapoptotic proteins Bcl-2 and/or Bcl-x(L). Adenovirus-mediated delivery of melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), a secreted cytokine having cancer-selective apoptosis-inducing properties, profoundly inhibits prostate cancer cell growth. However...
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