OBJECTIVE Cerebral microbleeds (MBs) have been previously associated with cognitive dysfunction, including Alzheimer's disease. In the present study, we aimed to clarify the relationship between cerebral lobar MBs and the regional cerebral blood flow (CBF). METHODS We investigated the data obtained from 122 patients in our memory clinic who were examined by both MRI and (99m)Tc-ethyl cysteina...

Several studies using single photon emission tomography (SPECT) have shown changes in cerebral blood flow (CBF) with age, which were associated with partial volume effects by some authors. Some studies have also demonstrated gender-related differences in CBF. The present study aimed to examine age and gender effects on CBF SPECT images obtained using the 99mTc-ethyl cysteinate dimer and a SPECT...

Increases in regional cerebral blood flow have been described in a variety of cerebral pathologic states, including stroke and seizure disorders. The usefulness of technetium-99m-labeled cysteinate dimer as a marker in the measurement of regional cerebral blood flow was tested in five cynomolgus monkeys. To expand the range of blood flow to beyond the normal limits, 40 mg/kg i.v. of the carboni...

J Nucl Med. Udalrich Buell, Michel C. De Roo and Robert A. Morgan Jean-Luc Moretti, Angelika Bischof-Delaloye, Thomas C. Hill, Pierre M. Rigo, Ronald L. Van Heertum, Peter J. Ell, B. Leonard Holman, Robert S. Hellman, Stanley J. Goldsmith, Ismael G. Mena, Jean Leveille, Paolo Gerundini Gherardi, Dimer in Normal Subjects and in Patients with Chronic Cerebral Infarction Biodistribution, Dosimetry...

BACKGROUND Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate dimer ([99mTc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status of MDD patients, and to explore an objective image assessment model of MDD which is non...

UNLABELLED Anatomical localization requires establishing an anatomical space within the image matrix. We developed a fast, fully automated method to establish the image orientation for 99mTc-ethylcysteinate dimer (ECD) brain SPECT images. METHODS The image orientation of ECD brain SPECT images was established in four stages. First, the brain surface was edge-detected as an isosurface at an ad...

We describe two cases of right hyperglycemia hemichorea (HGHC) with identical Tc-99m TRODAT-1/ Tc-99m ECD scan findings. While the brain MRI showed signal alterations within the left putamen, there was evidence of hyperperfusion on Tc-99m TRODAT-1 but hypoperfusion on Tc-99m ECD within the left putamen, in association with hyperperfusion within left thalamus on Tc-99m ECD. The discrepancy betwe...