نتایج جستجو برای: abcg1 protein
تعداد نتایج: 1235025 فیلتر نتایج به سال:
OBJECTIVE Maintenance of cholesterol homeostasis in human macrophages is essential to prevent foam cell formation. We evaluated the relative contribution of the ABCA1 and ABCG1 transporters to cholesterol efflux from human macrophages, and of the capacity of LXR agonists to reduce foam cell formation by stimulating export of cellular cholesterol. METHODS AND RESULTS ABCG1 mRNA levels were str...
RATIONALE Reduced plasma cholesterol and increased high-density lipoprotein (HDL) levels promote regression of atherosclerosis, in a process characterized by lipid unloading and emigration of macrophages from lesions. In contrast free cholesterol loading of macrophages leads to imbalanced Rac1/Rho activities and impaired chemotaxis. OBJECTIVE To study the role of HDL and the ATP-binding casse...
مقدمه: بیماری های قلبی آترواسکلروزیس نشات گرفته از آترواسکلروزیس، مهم ترین عامل مرگ و و میر در بیشتر کشورهاست. انتقال دهنده abcg1 مسئول ساخت و فرم دهی ذرات hdl بوده و به همین دلیل احتمالاً در جلوگیری از گسترش آترواسکلروزیسآتروسکلروزیس نقش دارد. هدف از این مطالعه بررسی تاثیر دو نوع تمرین تک جلسه ای(مقاومتی و استقامتی) بر بیان ژن abcg1 سلول های pbmn بود. روش بررسی: 24 نفر از بین بانوان ورزشکار خرا...
OBJECTIVE The objective of this study was to determine the effects and potential mechanisms of C-reactive protein (CRP) on cholesterol efflux from human macrophage foam cells, which may play a critical role in atherogenesis. METHODS AND RESULTS Human THP-1 monocytes and peripheral blood mononuclear cells (PBMCs) were preincubated with acetylated LDL and [3H]-cholesterol to form foam cells, wh...
Introduction: Atherosclerotic heart diseases are the most important causes of mortality in most countries. ABCG1 transporter is responsible for making and forming of HDL particles and therefore probably plays a crucial role in prevention of atherosclerosis. The purpose of this study was to assess the effect of two types of a single-session exercise (aerobic and resistance) on peripheral blood m...
Reverse cholesterol transport (RCT) is a mechanism critical to the anti-atherogenic property of HDL. Although citrulline contributes to the amelioration of atherosclerosis via endothelial nitric oxide production, it remains unclear whether it affects RCT. This study was undertaken to clarify the effects of citrulline on expressions of specific transporters such as ATP binding cassette transport...
OBJECTIVE The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis. METHODS AND RESULTS LDL receptor knockout (KO) mice were transplanted with bone marrow from ABCA1/ABCG1 double KO (dKO) mice. Plasma cholesterol levels after 6 weeks of Western-type diet (WTD) feeding were significantl...
Macrophages in the arterial intima take up modified LDL and become cholesterol-ester laden foam cells, which are the primary cell type in newly formed fatty streak lesions, and which play an important role throughout lesion progression and plaque vulnerability. Macrophages can unload their excess cellular cholesterol stores via lipid efflux, the first step in the protective reverse cholesterol ...
Diabetes exacerbates cardiovascular disease, at least in part through suppression of macrophage cholesterol efflux and levels of the cholesterol transporters ATP binding cassette transporter A1 (ABCA1) and ABCG1. The receptor for advanced glycation end products (RAGE) is highly expressed in human and murine diabetic atherosclerotic plaques, particularly in macrophages. We tested the hypothesis ...
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