Background Long-term use of levodopa (l-dopa) is inevitably complicated with highly disabling fluctuations and drug-induced dyskinesias, which pose major challenges to the existing drug therapy of Parkinson's disease. Methods In this study, we conducted a systematic review and meta-analysis to assess the efficacy of A2A receptor antagonists on reducing l-dopa-induced dyskinesias (LID). Resu...

The vertex Readiness Potential (RP) (Bereitschaftspotential) preceding self paced voluntary movements is reduced in duration and amplitude in patients with Parkinsonism. It cannot be used as an index for delayed initiation of movement. The negative potential is commonly replaced by a positive slow wave. In hemi-Parkinsonism, the abnormal RP is more apparent on moving the affected limb. The abno...

Parkinson's disease (PD) and focal dystonia (FD) are both predominantly characterized by motor symptoms. Also, recent research has shown that sensory processing is impaired in both movement disorders. FD is characterized by involuntary movements and abnormal limb postures; thus, abnormal kinesthesia could be involved in the pathogenesis. We examined passive index finger movements in patients wi...

Several authors have reported functional and therapeutic benefits after the application of electrical stimulation to children with neurological disorders (1-3). A functional movement can be induced by electrical neuromuscular stimulation of the paralysed muscles with intact excitability of their peripheral innervation. A long-term use of electrical neuromuscular stimulation can strengthen the w...

Seven cases of single ventricle, six cases of hypoplasia of the right heart (tricuspid atresia), and one case of hypoplasia of the left heart were investigated with reflected ultrasound. In hypoplasia of the right heart there was abnormal anterior movement of the mitral valve; in hypoplasia of the left heart, abnormal anterior movement of the tricuspid valve, and in single ventricle, similiar m...

In a bimanual slow matching task patients with asymmetric bradykinesia overestimated the movement of the more bradykinetic limb. Patients with drug induced or idiopathic asymmetric dyskinesia or dystonia, and patients with unilateral arm weakness underestimated movement of the abnormal limb. Bradykinesia may be caused by reduction, and dyskinesia and dystonia by exaggeration of corollary discha...

The basal ganglia are part of a neuronal network organized in parallel circuits. The "motor circuit" is most relevant to the pathophysiology of movement. Abnormal increment or reduction in the inhibitory output activity of basal ganglia give rise, respectively, to poverty and slowness of movement (i.e., Parkinson's disease) or dyskinesias.