Sperm motility and structural integrity are essential for successful fertilization in vivo, any hindrance of the correct assembly axoneme peri-axonemal structures sperm flagellum can lead to fertility problems. While there has been considerable advancement studying diseases related flagellum, underlying mechanisms that control movement not yet fully understood. In this study, we reveal tetratri...

background: pentoxifylline (px) prevents camp breakdown by inhibiting the activity of the camp-phosphatase and presumably, stimulates sperm motion. incubation with px causes hyperactivation of sperm, an important step in achieving fertilization, and leads to changes in membranes associated with sperm capacitation. objective: the purpose of this study was to examine the effects of pentoxifylline...

A fuzzy data fusion approach was used for human sperm morphology recognition analysis using 3-CCD camera image data. Fuzzy operators were used to create the relationship between abnormal sperm morphology and normal sperm aberrations after digitizing the images. The approaches have focused on frequencies of sperm with either abnormal morphology in semen analysis samples. In order to establish wh...

Objective Imbalance between production of reactive oxygen species (ROS) and total antioxidant capacity in testis, epididymis, and seminal fluid can eventually lead to subfertility and infertility. Abnormal chromatin packaging, and DNA fragmentation is considered as the main underlying causes. In this regard, we aimed to assess relationship between sperm parameters with DNA damage, protamine def...

Background: Heat-shock protein A2 (HspA2) is a testisspecific member of the HSP70 family known to play a critical role in spermatogenic cell differentiation. HspA2 is correlated with sperm maturity, function and fertility, and diminished expression of HspA2 results in abnormal sperm maturity and infertility. The aim of this study was to compare expression of HspA2 in fertile and infertile indiv...

Single structural defects involving the totality of ejaculated sperm are among rare cases of untreatable human male infertility. This form of infertility is of genetic origin and is generally transmitted as an autosomal recessive traits. Acrosome agenesis or globozoospermia results from perturbed expression of nuclear proteins or from an altered Golgi-nuclear recognition during spermiogenesis. ...

BACKGROUND Wide range of disorders ranging from genetic disorders to coital difficulties can influence male fertility. In this regard, genetic factors are highlighted as the most frequent, contributed to 10-15%, of male infertility causes. OBJECTIVE To investigate the influence of genetic abnormalities on semen quality and reproductive hormone levels of infertile men from Northeast China. M...

BACKGROUND Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. OBJECTIVE The objectives of this study were to search if these sera could induce DNA denaturation in sperm nucle...

Aim: To investigate the prevalence of high levels of sperm DNA damage among men from infertile couples with both normal and abnormal standard semen parameters. Methods: A total of 350 men from infertile couples were assessed. Standard semen analysis and sperm chromatin structure assay (SCSA) were carried out. Results: Ninety-seven men (28% of the whole study group) had a DNA fragmentation index...

BACKGROUND Testicular torsion due to oxidative stress results in infertility and testicular damage which can be preventable an important health problem worldwide. AIM The purpose of the present study was to investigate the changes of malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) levels; histopathological alterations; morphology, concentration and motilities...