Using the newly revised DSM-III-R criteria for substance-abuse diagnoses, we examined dependence syndrome elements among 83 psychiatric patients. The sample included 14 with no history of substance abuse. The remainder abused alcohol (52), sedatives (31), hallucinogens (12), stimulants (33), cannabis (44), cocaine (52), or opiates (47). Many patients (52) had abused more than one type of drug. ...

It has long been known that individuals will engage in voluntary inhalation of volatile solvents for their rewarding effects. However, research into the neurobiology of these agents has lagged behind that of more commonly used drugs of abuse such as psychostimulants, alcohol and nicotine. This imbalance has begun to shift in recent years as the serious effects of abused inhalants, especially am...

The purpose of this study is to identify a system for tracking the distribution increasingly abused prescription drugs. problems identified in was increase prescribed drugs falling into category that are frequently and as result improper systems place designed track such alongside normal drug networks. theories abuse highlight propensity increased rate amongst individuals why it has become impe...

DRUG abuse is a very serious problem. Because of man's search for new and different ways of inducing pleasurable feelings, the number of available pharmaceuticals has grown exponentially during the last few decades, as has societal use and dependence on medicines. Clearly, increased use has led to frequent abuse. Physicians should be aware of the many facets of drug abuse. It is now clear that ...

Adolescents and young adults of both sexes are the primary consumers of "club" drugs; yet, most of the mechanistic preclinical research in this area has been performed in adult male rodents. The purpose of this study was to evaluate the acute and repeated effects of drugs that are commonly abused by adolescents in female adolescent and adult rats in a rodent model of behavioral sensitization. D...

Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research. Drugs of abuse alter synaptic transmission, and these actions contribute to acute intoxication as well as the chronic effects of abused substances. Transmission at most mammalian synapses involves neurotransmitter acti...