STUDY OBJECTIVES To assess the relevance of various efficacy end points established for thromboprophylaxis trials, we compared the results of the fondaparinux phase III program in major orthopedic surgery using the original primary efficacy end point with those obtained when the efficacy end points recently suggested by the American College of Chest Physicians (ACCP) Consensus Conference on Ant...

OBJECTIVES Although effective strategies for the prevention of venous thromboembolism (VTE) are widely available, a significant number of patients still develop VTE because appropriate thromboprophylaxis is not correctly prescribed. We conducted this study to estimate the risk profile for VTE and the employment of adequate thromboprophylaxis procedures in patients admitted to hospitals in the s...

Four years after the 1st edition [1], the American College of Chest Physicians (ACCP) has published its 2nd edition of their evidence based clinical practice guidelines on the di‐ agnosis and management of lung cancer [2]. The goal of these guidelines is to assist chest physicians in achieving the best outcomes possible for their patients taking into account the new evidence based knowledge and...

To the Editor: We commend the excellent work by Jacobson et al. on behalf of the South African Society of Thrombosis and Haemostasis in producing a very necessary set of local guidelines on the management of venous thromboembolism (VTE).1 VTE is a major cause of morbidity and mortality, as highlighted recently by the United States Surgeon General.2 One important nuance worth noting, however, is...

BACKGROUND Pulmonary rehabilitation has become a standard of care for patients with chronic lung diseases. This document provides a systematic, evidence-based review of the pulmonary rehabilitation literature that updates the 1997 guidelines published by the American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation. METHODS The gui...

INTRODUCTION There is considerable controversy regarding the best method to prevent venous thromboembolism. In 2008, the American College of Chest Physicians (ACCP) published specific guidelines recommending the use of ow-molecular-weight heparin or warfarin, and a target international normalised ratio of 2.0-3.0 for a duration of at least 7-10 days, after elective knee arthroplasties. Many ort...

Abstract Pharmacoeconomics and outcomes research (PEOR) demonstrates the added value of health services and treatments and is used by a variety of individuals in numerous settings to optimize patient care. Currently, 51 PEOR fellowship programs are publicized on Web sites from organizations such as the American College of Clinical Pharmacy (ACCP), the International Society of Pharmacoeconomics ...

The social enterprise concept, a business with specific objectives, has been questioned by scholars and practitioners for its sustainability. More importantly, paucity of research exists on how can be sustainable, indicating the necessity developing sustainable model enterprise, particularly in Asian context. Filling gap literature, present study’s prime objective is to explore model. bodies kn...

INTRODUCTION High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor of joint damage and persistent disease activity. Survivin-positive patients are often poor responders to antirheumatic and biological treatment. The aim of this study was to investigate the reproducibility of survivin status and...

BACKGROUND Information about the variation in the risk for venous thromboembolism (VTE) and in prophylaxis practices around the world is scarce. The ENDORSE (Epidemiologic International Day for the Evaluation of Patients at Risk for Venous Thromboembolism in the Acute Hospital Care Setting) study is a multinational cross-sectional survey designed to assess the prevalence of VTE risk in the acut...