We and others have shown that regulatory T cells (Treg) accumulate dramatically with age in both humans and mice. Such Treg accrual contributes to age-related immunosenescence as they reduce the response to tumors and parasite infection. While we reported earlier that aged Treg have decreased expression of the pro-apoptotic molecule Bim and germline deletion of Bim promoted earlier accumulation...

BACKGROUND The new National Cancer Institute (NCI) Community Oncology Research Program (NCORP) went live August 1, 2014; 34 sites were selected for the program, including 7 new sites that previously did not have a research grant from the NCI. This report describes the first year of a new program site. METHODS Accrual, investigator and site participation, and number of open studies by the prog...

This study presents empirical evidence concerning the effect of different accounting standard on earnings management. Prior studies have shown that accounting standards influence earnings management. Tighter accounting standards regime restricts management’s descretion to manipulate accruals, and at the same time, induce more costly real earnings management activities. To investigate this iss...

Objectives The current study aimed to investigate the pathogenesis of obesity-induced impaired bone mass accrual and impact dietary intervention on density in mouse model obesity. Methods Mice were fed with chow diet (CD) for 10 months, high-fat-diet (HFD) or HFD 6 months then transferred 4 (HFDt). Results Weight loss decreased intrahepatic lipid accumulation observed mice following interventio...