introduction: dill (anethum graveolens), a herb from from umbelliferae, is used traditionally to treat convulsion and increasing milk production. its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and gastric acid secretion reducing effect have been reported. the spasmolytic effect of dill fruit on rat uterus has also been shown recently. the aim of present study was to i...

background& objectives: zataria multiflora boiss is used in traditional medicine to treat gastrointestinal disorders and menorrhagia. the inhibitory effect of this herb on rat uterus contractions has also been reported. the aim of this study was to investigate the effect of zataria multiflora boiss hydroalcoholic leaf extract (zhle) on isolated rat ileum in presence of some known ileum stimulan...

Nerve activity is known to be an important regulator of muscle phenotype in the adult, but its contribution to muscle development during embryogenesis remains unresolved. We used the zebrafish embryo and in vivo imaging approaches to address the role of activity-generated signals, acetylcholine and intracellular calcium, in vertebrate slow muscle development. We show that acetylcholine drives i...

Condensed tannins (CTs) extracted from various plants have been shown to possess antioxidant, antidiabetic, anthelmintic, anti-palatable and anti-diarrhea activity. Black currant (Ribes nigrum L.), a native plant of northern Europe Asia, is rich in phenolic compounds, including CTs. Among the biological activities CTs, their astringent property likely affect gastrointestinal motility. This stud...

Botulinum toxin (BTA) is a bacterial-derived extract that can inhibit muscle contraction, acting directly on the absorption of acetylcholine. Thanks to this property, botulinum has been used in aesthetic and general medicine for several years. Nowadays, use being deepened address problem bruxism. In scoping review, results studies literature last 10 years were analyzed. Indeed, 12 reports (foun...

Histone deacetylases (HDACs) are a family of enzymes that mediate nucleosomal histone deacetylation and gene expression. Some members of the HDAC family have also been implicated in nonhistone protein deacetylation, which modulates cell-cycle control, differentiation, and cell migration. However, the role of HDACs in smooth muscle contraction is largely unknown. Here, HDAC8 was localized both i...

To elucidate the altered function of the lower esophageal sphincter (LES) in gastroesophageal reflux disease (GERD), we evaluated the motility proximal to LES using force transducers, contraction and relaxation responses to neurotransmitters in LES strips, and gene expression of neurotransmitter receptors in GERD rats. Force transducers were applied to the proximal LES, and contraction of the L...

The rat vas deferens was removed and either transplanted alongside the soleus muscle or into the bed of the soleus muscle that had previously been removed, and in this case the soleus nerve was connected to the transplant. The vas deferens reinnervated by the somatomotor nerve recovered the best. Contractions to transmural electrical stimulation could not be elicited from the denervated vas def...

background: teucrium polium has been known as an important traditional medicinal plant and is used for different therapeutic purposes such as gastrointestinal disorders. therefore, the anti-spasmodic and antinociceptive activities of aqueous extract of teucrium polium w as examined. methods: anti-spasmodic effect of different concentrations (47-470 mg/l) of teucrium polium extract was assessed ...