Study objective: To assess the utility of urinary uric acid excretion as a marker of nocturnal hypoxia in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after the institution of nasal continuous positive airway pressure (CPAP). Design: Prospective, open. Setting: Sleep Disorders Laboratory, Veterans Affairs Medical Center. Participants: Thirty consecutive male subjec...

In the early studies on atromid, which is ethyl p-chlorophenoxyisobutyric acid (clofibrate or C.P.I.B.) with androsterone, Thorp (1962) reported that, in monkeys, this preparation increased uric acid excretion in addition to lowering plasma lipids. Also Oliver (1962) reported that atromid lowered serum uric acid levels in patients with ischaemic heart disease. We therefore investigated its poss...

The effect of pyrazinamide on serum uric acid and urinary excretion of uric acid was studied in patients with pulmonary tuberculosis. A rise in serum uric acid concentration during drug therapy was associated with a fall in urinary excretion of uric acid. No significant difference was observed between two and three months of drug administration. one out of twenty patients developed arthralgia (...

We report a model of prostaglandin depletion induced in rats by fasting for 11 days, followed by institution of an essential fatty acid-deficient diet. Urinary prostaglandin E, 2 weeks after this diet had been implemented, was 22 +/- 2 ng/24 hours compared to 113 +/- 8.5 ng/24 hours in controls (P less than 0.01). There was no difference in 24-hour urine volume or solute excretion in controls a...