The design of a FIFO buffer supporting synchronisation-free, non-blocking, reading and writing operations is presented. The circuit consists of a standard self-timed FIFO surrounded by two interface blocks, In and Out, which together provide temporal independence between the reader and writer processes. These blocks are synthesised from their Signal Transition Graph (STG) specifications using a...

by discovering how chemical compounds/xenobiotics cytotoxicity is affected when their metabolic pathways are inhibited or activated, the metabolic pathways that activate versus detoxify chemical compound can be identified. reactive metabolites contributing to cytotoxicity can also be identified. in this lecture, the pretreatment of inhibitors and activators of xenobiotic metabolizing enzymes as...

ACMs have been demonstrated to be highly suitable as image segmentation models for computer vision tasks. Among other ACM, the local region-based show better performance because they extract information regarding intensity in neighborhood and embed it into energy minimization function guide active contour boundary of desired object. However, online noisy inhomogeneous is still a challenging tas...

Abstract A requirement of the oil spill response industry is its ability to develop highly trained staff international backgrounds who have a holistic understanding techniques and all meet standard baseline competency provide an when required. As solution this Oil Spill Response Ltd (OSRL) has developed thirteen-week Advanced Responder training course aims bring delegates from member companies ...

Aerodynamic bearings with elastically supported tilting pads have operational properties comparable with widely-used foil journal bearings. They combine the excellent stability of tilting pad bearings, as a result of very small cross-coupling stiffness terms, with the positive properties of foil bearings, namely their ability to adapt to changing operating conditions and presence of additional ...

Purpose: Characterization of the D-glucose tnnsport acms isolated normal and diabetic rabtnt retmal vessels wing " in vitro " lriicmpxfusicm techniques. Methods: After manual dissection and caonulation of normal and diabetic retinal vessels, they were penis4 with %D-gluar;e and 'H-inulin and studied under different cqcrimental conditions. Results We observed in normal retinal vessels a signific...

This paper presents a novel formal development of a non-trivial parallel program: Simpson's implementation of asynchronous communication mechanisms (ACMs). Although the correctness of the "4-slot algorithm" has been shown elsewhere, earlier developments are by no means intuitive. The aims of this paper include both the presentation of an understandable (yet formal) design history and the establ...

The molecular basis underlying the dedifferentiation of mammalian adult cardiomyocytes (ACMs) into myocyte-derived cardiac progenitor cells (mCPCs) during cardiac tissue regeneration is poorly understood. We present data integrating single-cell transcriptome and whole-genome DNA methylome analyses of mouse mCPCs to understand the epigenomic reprogramming governing their intrinsic cellular plast...

6- Mercaptopurine (6-MP) is widely used in clinic as an immunosuppressive for treatment of acute lymphocytic leukemia, Crohn's disease, and ulcerative colitis with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of 6-MP against isolated rat hepatocytes were searched in this study using “Accelerated Cytotoxicity Mechanism Screening (ACMS)” techniques. The co...

The sensitivity of planetary boundary layer (PBL) parameterization schemes in a marine jet and associated precipitation is investigated this study. Six PBL the Weather Research Forecasting Model, including YSU, MYJ, MYNN, ACM2, BouLac, UW schemes, are examined simulating (BLJ) over South China Sea coastal during warm-sector heavy rainfall event (19–20 May 2015) near coast China. results show th...