ADVERTISEMENT RETURN TO ISSUEPREVFirst ReactionsNEXTTotal Synthesis of Poisonous Aconitum Alkaloids Empowered by a Fragment Coupling StrategyConvergent total synthesis highly complex bridged alkaloids through key fragment coupling.Bastien Nay​Bastien NayLaboratoire de Synthèse Organique, Ecole Polytechnique, CNRS, ENSTA, Institut Polytechnique Paris, Palaiseau 91128, FranceEmail: [email protect...

THE TITLE COMPOUND [SYSTEMATIC NAME: (1α,3α,6α,8β,13β,14α,16β)-20-ethyl-8-eth-oxy-3,13-dihy-droxy-1,6,16-trimeth-oxy-4-(meth-oxy-meth-yl)aconitan-14-yl 4-meth-oxy-benzoate], C(35)H(51)NO(10), was isolated from roots of Aconitum carmichaeli Debx., which is a typical C(19)-diterpenoid alkaloid. The mol-ecule has an aconitane carbon skeleton with four six-membered rings and two five-membered rings...

THE TITLE COMPOUND [SYSTEMATIC NAME: (1S,4S,5R,7S,8S,9R,10R,11S,13S,14S,16S,17R)-N-methyl-8,14-dihy-droxy-1,16-tri-meth-oxy-4-(meth-oxy-methyl-ene)aconitane], C(24)H(39)NO(5), was isolated from the roots of Aconitum carmichaelii Debx., which is known as 'Chuanwu' in Chinese traditional herbal medicine. The mol-ecule has an aconitane carbon skeleton with four six-membered rings and two five-memb...

Simultaneous determination of four aconitine analogues (ACs) (AC; aconitine, HA; hypaconitine, JA; jesaconitine, MA; mesaconitine) in leaves and roots of wild Aconitum plants (Aconitum japonicum THUNBERG, Aconitum okuyamae Nakai) was carried out to elucidate the relation between toxicity to mice and ACs content determind by liquid chromatography tandem mass spectrometry. The total amounts of AC...

The herbal medicinal genus Aconitum L., belonging to the Ranunculaceae family, represents the earliest diverging lineage within the eudicots. It currently comprises of two subgenera, A. subgenus Lycoctonum and A. subg. Aconitum. The complete chloroplast (cp) genome sequences were characterized in three species: A. angustius, A. finetianum, and A. sinomontanum in subg. Lycoctonum and compared to...

In the course of the isolation of atisine from the roots of Aconitum heterophyllum of commercial origin, as presented in Paper VIII (I), it was noted that further concentration of the final mother liquors from atisine hydrochloride yielded a thick solution which on longer standing gave an additional crystalline fraction. It was then found that this fraction (10 gm. from 24 kilos of root) consis...

The chemical constituents from Aconitum richardsonianum var. pseudosessiliflorum were investigated. The roots of this plant were extracted three times with 90% EtOH at the room temperature. The ethanol extracts were combined and concentrated under reduced pressure to yield residue, which was suspended in water and successively partitioned with chloroform. The chloroform extraction was isolated ...

Aconitine (AC), mesaconitine (MA), and hypaconitine (HA) are the active alkaloids identified in aconite tuber, an important traditional Chinese medicine. The study is aimed to investigate their intestinal transport profiles and potential interaction during the intestinal absorption using the Caco-2 cell monolayer model. All three alkaloids had good permeability with P(app) values greater than ...