Canada's per capita use of intravenous immune globulin (IVIG) grew by approximately 115% between 1998 and 2006, making Canada one of the world's highest per capita users of IVIG. It is believed that most of this growth is attributable to off-label usage. To help ensure IVIG use is in keeping with an evidence-based approach to the practice of medicine, the National Advisory Committee on Blood an...

A 62-year-old man having prostate cancer presenting with hemolytic jaundice is reported. The hemolytic jaundice was cured by diethylstilbestrol diphosphate (DES-P) treatment, but the patient died one year and two months later from relapse of prostate cancer. An autopsy confirmed the diagnosis of prostate cancer with multiple metastases. Sudden anemia caused by bone metastasis might have caused ...

Human parvovirus B19 (PV-B19) causes erythema infectiosum, hydrops fetalis, and transient aplastic crisis in immunocompromised patients with chronic hemolytic anemia, arthralgia, and chronic pure red cell aplasia [1]. It may also cause autoimmune hemolytic anemia [2] (which presents as aplastic crisis with reticulocytopenia or increased erythropoiesis with reticulocytosis) [3], autoimmune throm...

By J. V. DAdE, M.B., M.R.C.P. LONDON H YDROGEN ion concentration has a controlling effect upon many hemolytic systems, both simple and complex. Osbor& in 1934 reviewed the early literature on the effect of pH on the hemolysis by complement of corpuscles sensitized by hemolytic immune body. He found that the optimum reaction for the hemolysis of sheep corpuscles by guinea pig serum was about pH ...

Hemosiderinuria caused by intravascular hemolysis is a characteristic clinical feature of an acquired hemolytic disorder, paroxysmal nocturnal hemoglobinuria (PNH). We examined the deposition of hemosiderin (iron) in the kidneys of 6 patients with PNH using magnetic resonance imaging (MRI). Three patients with autoimmune hemolytic anemia (AIHA), a hemolytic disorder showing extravascular hemoly...

common itl hemolytic anemia. In a case described by Baty,’ the reticulocytes numbered 92 per cent. There is no completely satisfactory explanation of the nature of hemolytic crisis, nor of the mechanisms responsible for the recovery phenomenon. Lepel2 and Dameshek and Schw-art.z3 pointed out the similarity betw-eetl the various phenomena observed in the hemolytic anemia of humans w-ith those ob...

Thrombotic thrombocytopenic purpura (TTP) is rare but life-threatening disease, characterized typically by microangiopathic hemolytic anemia (MAHA), profound peripheral thrombocytopenia and severe deficiency in the von Willebrand factor-cleaving prortease ADAMTS13. It has been reported that acquired immune TTP is closely associated with human immunodeficiency virus infection and influenza infec...

Pernicious anemia is an autoimmune disease with a variety of clinical presentations. We describe a case of pernicious anemia presenting with pancytopenia with hemolytic features. Further workup revealed very low vitamin B12 levels and elevated methylmalonic acid. It is important for a general internist to identify pernicious anemia as one of the cause of pancytopenia and hemolytic anemia to avo...

Thrombotic thrombocytopenic purpura (TTP) is a rare but fatal thrombotic microangiopathy. Circulating AntiADAMTS13 antibodies produced in response to various triggering events, such as vaccinations, autoimmune disorders, malignancy, and administration of several drugs lead acquired TTP (aTTP). This case concerns 26-year-old male with aTTP after receiving the second dose Covishield vaccine (Oxfo...

INTRODUCTION Sickle cell anemia and thalassemia result in impaired bone health in both adults and youths. Children with other types of chronic hemolytic anemia may also display impaired bone health. STUDY DESIGN To assess bone health in pediatric patients with chronic hemolytic anemia, a cross-sectional study was conducted involving 45 patients with different forms of hemolytic anemia (i.e., ...