Acquired hemophilia A (AH) is an auto-immune disorder cause by polyclonal auto-antibodies (inhibitors) to clotting factor VIII (FVIII). Glucocorticoids (GC) are a standard initial approach to elimination of these inhibitors and are successful in approximately 30% when used alone and about 60% when used in combination with other immuno-modulating therapies. However, the mechanism of action and e...

Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3(-)NKp46(+)CD56(+) cells that can be cytotoxic and/or produce high amounts of cytokines such as ...

Developers of cancer immunotherapy have struggled for decades to achieve clinical success in using the patient's immune system to treat cancer. In the absence of a defined development paradigm for immunotherapies, conventional criteria established for chemotherapy were applied to these agents. This article summarizes the recent lessons for development of agents in the immunotherapy space, descr...

Although the advent of new immunotherapy approaches has improved survival for many patients with advanced malignancies, the high degree of nonresponders, especially in highly prevalent malignancies including breast, colon and prostate cancers was also a strong reminder that we possess only partial understanding of the events underlying the immune resistance of tumors. Considerable evidence indi...

MicroRNAs (miRNAs) are small non-coding RNA species that can bind to both untranslated and coding regions of target mRNAs, causing their degradation or post-transcriptional modification. Currently, over 2500 miRNAs have been identified in the human genome. Burgeoning evidence suggests that dysregulation of human miRNAs can play a role in the pathogenesis of a variety of diseases, including canc...

This study describes the stomatological findings reported on 20 Peruvian patients infected by the human AIDS virus. Lesions occurring most frequently were: xerostoma (80%), pseudomembranous candidiasis (70%), commissural cheilitis (55%), atrophy of filiform papillae (40%), ulcerative lesions (30%), vellous leucoplasia (25%) and erithematose or atrophic candidiasis (25%). Prevalence of the diver...

To determine the visual outcome, progression, and complications of patients with acquired immuno-deficiency syndrome-related cytomegalovirus (CMV) retinitis treated with intravitrealfoscarnet (2.4 mg in 0.1 ml per injection), a retrospective study was carried out in 193 patients. Induction therapy consisted of two injections a week until the lesions were inactive. Maintenance therapy consisted ...

Submit Manuscript | http://medcraveonline.com Abbreviations: HTLVs: Human T-Cell Lymphotropic Viruses; HTLV-1: Human T-Cell Lymphotropic Virus Type 1; HTLV2: Human T-Cell Lymphotropic Virus Type 2; HIV: Human Immunodeficiency Virus; STLV-1: Simian T-Cell Lymphotropic Virus Type 1; PWIDs: People Who Inject Drugs; IDU: Intravenous Drug Use; AIDS: Acquired Immune Deficiency Syndrome; HBV: Hepatiti...

The recognition that the development of cancer is associated with acquired immunodeficiency, mostly against cancer cells themselves, and understanding pathways inducing this immunosuppression, has led to a tremendous development of new immunological approaches, both vaccines and drugs, which overcome this inhibition. Both "passive" (e.g. strategies relying on the administration of specific T ce...

We report on fast beam-scanning stimulated-emission-depletion (STED) microscopy in the visible range using for resolution enhancement compact, low cost and turn-key continuous wave (CW) fiber lasers emitting at 592 nm. Spatial resolutions of 35 to 65 nm in the focal plane are shown for various samples including fluorescent nanoparticles, immuno-stained cells with a non-exhaustive selection of 5...