This study analyzed clinically actionable pharmacogenotypes for clopidogrel, warfarin, statins, thiopurines, and tacrolimus using microarray data for 2121 participants (55-85 years) from the Australian Hunter Community Study (HCS). At least 74% of participants (95% confidence interval [CI]: 72%-76%) had strong level evidence for at least one medium- or high-risk actionable genotype that would t...

This paper overviews NTCIR-13 Actionable Knowledge Graph (AKG) task. The task focuses on finding possible actions related to input entities and the relevant properties of such actions. AKG is composed of two subtasks: Action Mining (AM) and Actionable Knowledge Graph Generation (AKGG). Both subtasks are focused on English language. 9 runs have been submitted by 4 teams for the task. In this pap...

Toward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct prospective whole-exome and transcriptome sequencing of bone or soft tissue tumor biopsies from a cohort of 150 mCRPC affected individuals. Aberrations of AR, ETS genes, TP53, and PTEN were frequent ...

Big data and learning analytics for higher education is a rapidly growing field with disruptive potential. However, there has been little research reported on a pedagogic method that helps to create an actionable policy from big data. In recent years, there is a meaningful debate that big data alone cannot improve teaching, and more research is needed from a pedagogic point of view. We, therefo...

The theoretical simplicity of contrasting the notion of energetic search of Baron and Fiet with that of alertness (without search) of Kirzner have been winning over more complex yet more actionable formulations. In contrast, this paper introduces a less dogmatic and more actionable integrated framework that could be viewed as either passive search or active alertness. By investigates how the th...

In the domain of Galleries, Libraries, Archives and Museums (GLAM) institutions, creative innovative tools methodologies for content delivery user engagement have recently gained international attention. New methods been proposed to publish digital collections as datasets amenable computational use. Standardised benchmarks can be useful broaden scope machine-actionable promote cultural linguist...

BACKGROUND Population-based screening for atrial fibrillation (AF) is a promising public health strategy to prevent stroke. However, none of the published reports have evaluated comprehensive screening for additional stroke risk factors such as hypertension and diabetes in a pharmacy setting. METHODS The Program for the Identification of 'Actionable' Atrial Fibrillation in the Pharmacy Settin...

PURPOSE We report the experience with 2,000 consecutive patients with advanced cancer who underwent testing on a genomic testing protocol, including the frequency of actionable alterations across tumor types, subsequent enrollment onto clinical trials, and the challenges for trial enrollment. PATIENTS AND METHODS Standardized hotspot mutation analysis was performed in 2,000 patients, using ei...