The reformulation of amphotericin B (AMB) into a lipid complex (AMB lipid complex [ABLC]) or liposomal carrier (liposomal AMB [L-AMB]) changes the rate and extent of drug distribution to the lung. The importance of pharmacokinetic differences among the various lipid AMB formulations in the treatment of invasive pulmonary aspergillosis (IPA) remains unknown. We compared the kinetics of AMB lung ...

A noncovalent, water-soluble complex of amphotericin B (AMB) and poly(α-glutamic acid) (PGA), with AMB loadings ranging from 25 to 55% (wt/wt) using PGA with a molecular weight range of 50,000 to 70,000, was prepared as a potential new treatment for visceral leishmaniasis (VL). The AMB-PGA complex was shown to be as active as Fungizone (AMB deoxycholate) against intracellular Leishmania donovan...

in this paper the problem on “magnetic fluid lubrication of porous-pivoted slider bearing with slip velocity by n ahmad et.al.[7]” has been recapitulated using jenkin’s model [4] with the additional effect of squeeze velocity of the above plate. it is found that while discussing the above problem, [7] has stated but ignored the term , where +, in their study (refer equation(2.2)). this paper re...

Bacterial cell surface display is a widely used technology for bioadsorption and for the development of a variety of screening systems. Magnetotactic bacteria are unique species of bacteria due to the presence of magnetic nanoparticles within them. These intracellular, nanosized (50 to 100 nm) magnetic nanoparticles enable the cells to migrate and be manipulated by magnetic force. In this work,...

Flywheels are used for peak shaving or load smoothing to generate a higher efficiency and more stable power supply. Therefore, this paper investigates highly integrated outer rotor flywheels levitated by active magnetic bearings (AMB). Due the gyroscopic behavior diametrical enlargement under rotation, system changes with speed, leading significant decrease in maximum force slew rate of AMB. Th...

Abstract: In this paper, the nonlinear dynamical behaviors of an active magnetic bearing-rotor system are investigated using numerical simulation. Firstly, the nonlinear magnetic force is obtained by Taylor series. Secondly, the primary-internal resonance of an AMBRS(active magnetic bearing) -rotor system is studied with the help of LungKutta method. To analyze the motion characters of system, ...

OBJECTIVES Amphotericin B (AmB) is a drug of choice for treatment of disseminated fungal infections, but its use is often associated with severe adverse effects. Our observation that generic formulations of AmB contain multiple polyene components led us to propose that removal of other polyenes would yield a high purity AmB (AmBHP) with an improved therapeutic index. METHODS To test that prem...

Antti Kärkkäinen Dynamic Simulations of Rotors during Drop on Retainer Bearings Lappeenranta, 2007 91 p. Acta Universitatis Lappeenrantaensis 279 Diss. Lappeenranta University of Technology ISBN 978-952-214-444-7; ISBN 978-952-214-445-4 (PDF) ISSN 1456-4491 The active magnetic bearings have recently been intensively developed because of noncontact support having several advantages compared to c...