Nalidixic acid (Negram) is an antimicrobial agent widely used in the treatment of urinary tract infection. Some years ago Boreus and Sundstrom (1967) reported intracranial hypertension in a 6-month-old boy treated with nalidixic acid at the manufacturer's recommended dose. Only a few cases have been reported since, mostly in children treated either with large doses (Fisher, 1967) or for prolong...

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease and stroke. However, the potential benefits of creatine for patients with convu...

acute yew (taxus baccata) intoxication was induced in 7 adult sheep by oral administration of the plant materials at the dose of 2.5g/kg body weight. blood samples for hematology and serum biochemistry were collected before and after the induced intoxication.electrocardiography was performed using a base-apex lead. intoxicated animals displayed lethargy, depression, bradycardia and varying inte...

Abstract Funding Acknowledgements Type of funding sources: None. Aims Cardiac tamponade (CT) is the most common life-threatening complication interventional electrophysiology. Urgent drainage by percutaneous pericardiocentesis and anticoagulation reversal are required. Immediate direct protamine administration to pericardial space patient has not been described. This study was designed assess e...