Thirty-nine adults with acute leukaemia who had relapsed when receiving extensive chemotherapy were treated with a combination of methotrexate and colaspase (L-asparaginase) given sequentially. Patients initially received 50-80 mg/m(2) methotrexate, followed three hours later by intravenous colaspase, 40 000 IU/m(2). Seven days later intravenous methotrexate, 120 mg/m(2) was given. Each dose of...

Background: An earlier case-control study from Western Australia reported a protective effect of maternal folic acid supplementation during pregnancy on the risk of childhood acute lymphoblastic leukaemia (ALL). The present study tested that association.

OBJECTIVE To explore the possible association between intramuscular vitamin K given to neonates and the subsequent development of childhood cancer. DESIGN Retrospective case-control study on the basis of hospital records. SETTING The former Northern Health region of England. SUBJECTS 685 children who were born and lived in the region and who developed cancer before their 15th birthday, an...

The study included 1742 patients with acute myeloblastic leukaemias (AML) and acute lymphoblastic leukaemias (ALL), Kyiv city residents and patients from 20 regions of Ukraine. Bone marrow and blood smears were sent at diagnosis to Reference Center. The analysis was based on May-Grünvald-Giemza (MGG) stain and cytochemical reactions (MPO, acNSE, CAE, AP, PAS). Immunocytochemical techniques (APA...

OBJECTIVE To study the outcome of children with acute lymphoblastic leukaemia who were treated using a protocol including one or two delayed intensifications. DESIGN Prospective single-arm multicentre study. SETTING Five designated children cancer units of the Hospital Authority of Hong Kong. PATIENTS Children aged between 1 and 17.9 years with newly diagnosed acute lymphoblastic leukaemi...