Spontaneous remission or regression of cancer is defined as partial or complete disappearance of malignant disease temporarily or permanently in the absence of any specific treatment. The condition is named spontaneous regression for solid tumors and spontaneous remission (SR) for leukemia [1]. Spontaneous remission has been reported in different hematological malignancies. It has been observed...

By Alvin M. Mauer I T IS TRULY gratifying to review the progress that has been made in the therapy of the acute leukemias since the introduction of aminopterin by Farber and coworkers’ in the late I 940s. This progress can be measured by the increasing proportion of patients who have achieved complete remission, the increasing duration of their survival, and the increasing evidence that for som...

The immunosuppressive effects of maintenance combination chemotherapy given for periods ranging from 8 to 28 months to 20 children with acute lymphocytic leukemia in remission were investigated. There was depression of both the primary antibody production to the hemagglutinin antigen of the Hong Kong influenza virus and the anamnestic response to the neuraminidase of the same virus. The primary...

introduction: heterochromatin consists of dna sequences that are not transcribed, and are repeated in short tandem at heterochromatic regions of chromosomes 1, 9, 16 as well as the distal part of long arm of chromosome y. slightly large tandem repeats at the centromeres of human chromosomes are also considered as heterochromatin regions. the main aim of the present study is to evaluate the hete...

Five patients with lymphocytic malignancies were found to have structural aberrations of chromosome 14, all involving band q11. The malignant cells of all five cases were analyzed by immunofluorescence to establish immunologic phenotypes. Three patients had T lymphoblastic lymphoma/leukemia with mediastinal masses (cases 1, 2, and 3); one patient had peripheral T cell lymphoma (case 4); and one...

The French-American-British (FAB) and WHO classifications provide important guidelines for the diagnosis, treatment, and prognostic prediction of acute leukemia, but are incapable of accurately differentiating all subtypes, and not well correlated with the clinical outcomes. In this study, we performed the protein profiling of the bone marrow mononuclear cells from the patients with acute leuke...

BACKGROUND Morphology and cytochemistry are the foundation for classification of leukemias in dogs and cats. Advances in automated hematology instrumentation, immunophenotyping, cytogenetics, and molecular biology are significantly improving our ability to recognize and classify spontaneous myeloproliferative and lymphoproliferative disorders. OBJECTIVE The purpose of this study was to assess...

PURPOSE In the 1970s and 80s, standard treatment for childhood acute lymphocytic leukemia (ALL) included both intrathecal methotrexate and whole-brain irradiation. During acute treatment, seizures were not uncommon. The development of intractable epilepsy years after treatment, however, has not been well described in the literature. We describe five patients who were treated for acute lymphocyt...