specified (AML-NOS), AML with myelodysplasia-related changes (AML-MRC), multilineage dysplasia (MLD). Abstract The WHO classification of acute myeloid leukemia (AML) is hierarchically structured and integrates genetics, data on patients' history, and multilineage dysplasia (MLD). The

Tumor-propagating cells in acute leukemia maintain a stem/progenitor-like immature phenotype and proliferative capacity. Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) originate from different lineages through distinct oncogenic events such as MLL fusions and Notch signaling, respectively. We found that Zfx, a transcription factor that controls hematopoietic stem cell s...

background: acute myeloid leukemia, as most cancers, results from exposure to carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. the present case-control study measures the relationship between glutathione s-transferase (gst) t1 and m1 null genotypes and the risk of acute myeloid leukemia. methods: we identified the gstt1 andgstm1 genotypes by multiplex polymera...

background: acute leukemias are characterized by neoplastic proliferation of hematopoietic stem cells and accumulation of blasts and immature cells in the bone marrow. we applied a selective panel of immunohistochemical markers on bone marrow trephine tissue sections and observed their utility in diagnosis and typing of acute leukemia. materials and methods: the study was done at psg institute ...

To gain insight into the differential mechanism of gene promoter hypermethylation in acute and chronic leukemia, we identified the methylation status on one part of 5'CpG rich region of 8 genes, DAB2IP, DLC-1, H-cadherin, ID4, Integrin alpha4, RUNX3, SFRP1, and SHP1 in bone marrows from acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients. Also, we compared the methylation s...

Alterations of TWIST-1 expression are often seen in solid tumors and contribute to tumorigenesis and cancer progression. However, studies concerning its pathogenic role in leukemia are scarce. Our study shows that TWIST-1 is overexpressed in bone marrow mononuclear cells of patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Gain-of-function and loss-of-function analy...

background: interaction between killer cell immunoglobulin-like receptors (kir) and human leukocyte antigen (hla) class i molecules is important for regulation of natural killer (nk) cell function. objective: the aim of this study was to investigate the impact of compound kir-hla genotype on susceptibility to acute leukemia. methods: cohorts of iranian patients with acute myeloid leukemia (aml;...

objective: this study was conducted to evaluate serum trace elements level, selenium (se), zinc (zn), and copper (cu) at the diagnosis of acute leukemia, and also if there is any difference in their serum levels among various subtypes of disease. subjects: fifty newly-diagnosed acute leukemia patients before starting therapy and fifty healthy subjects were entered into the study. methods: serum...

acute myeloid leukemia (aml-m7) is a type of pediatric aml accounting for 3–10% of primary childhood aml and children may present with a broad variety of symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions. we report a rare case of aml .a 26-month-old boy who presented with weakness and fatigue. he was diagnosed as a case of amlm-7...