Little is known about how aerobic exercise affects Alzheimer's disease (AD). The purpose of this pilot study was to test the impact of 6-month cycling on AD symptoms in community-dwelling older adults with mild-to-moderate AD, using a single-group, repeated-measures design (n = 26). AD symptoms were measured with the AD Assessment Scale-Cognitive (ADAS-Cog), Disability in AD (DAD), and Neuropsy...

the role of transforming growth factor (tgf)-β1, interferon (ifn)-γ, interleukin (il)-2, il-3, and il-6 in the pathogenesis of alzheimer's disease (ad) has long been reported in literature. in this case-control study, the concentrations of these cytokines in altered t lymphocytes, as well as serum vitamin b12, have been compared in terms of factors such as, age, the clinical course and the pati...

Centella asiatica ( léi gōng gēn) is a traditional medicinal herb with high antioxidant activity, which decreases amyloid-β (Aβ) deposition in the brain. At the same time, aggregated Aβ-induced oxidative stress is the trigger in the pathogenesis of Alzheimer's disease (AD). Here, we investigated the ability of C. asiatica ethanol extract (CAE) to protect PC12 and IMR32 cells from Aβ1-40-induced...

Justice means giving rights to all right-holders without exaggeration or shortcoming. It is an absolute subject for every time and place. sometimes equality, example, not making any distinction between classes in the community their duties, rights, rewards punishments. However, equality relative it opposite of justice because fair reward someone who works hard same way as doesn’t. Khalifa Abuba...

Background Sleep abnormalities may play a prominent role in the pathogenesis or exacerbation of Alzheimer’s disease (AD). is considered modifiable target for prevention and treatment. Racial sleep health disparities exist, contribute to disproportionately increased risk developing AD associated with being African American. Yet, relationships between pathophysiology American individuals are unde...

Atopic dermatitis (AD) not only changes the life of the affected child but also affects the physical, social and emotional functioning of parents. The aim of the study was to assess the quality of life of parents of children with AD and to correlate it with the disease severity. It was a cross sectional, self-administered questionnaire study performed in parents of children with AD attending de...

Folate metabolism, also known as one-carbon metabolism, is required for several cellular processes including DNA synthesis, repair and methylation. Impairments of this pathway have been often linked to Alzheimer's disease (AD). In addition, increasing evidence from large scale case-control studies, genome-wide association studies, and meta-analyses of the literature suggest that polymorphisms o...

BACKGROUND Lowering cholesterol is associated with reduced CNS amyloid deposition and increased dietary cholesterol increases amyloid accumulation in animal studies. Epidemiologic data suggest that use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) may decrease the risk of Alzheimer disease (AD) and a single-site trial suggested possible benefit in cognition w...

BACKGROUND A proliferation-inducing ligand (APRIL) is a tumor necrosis factor (TNF) superfamily member ligand that stimulates B cells in vitro and in vivo. It also plays an important role in T cell activation and survival. OBJECTIVES This study was conducted to evaluate serum levels of APRIL in patients with atopic dermatitis (AD) and vitiligo and their correlation with disease activity. ME...