this report is related to a female 7-year-old crossbreed sheep whose right eye had been protruded andswelling of upper eyelid was observed. routine enucleating was performed. histopathological evaluation ofeyelid revealed coincidence of two kinds of neoplasms. the first part was composed of multiple lobules ofsebocytes, which were detected as meibomian adenoma. the second section included infil...

Hepatocellular adenoma is a very rare disease in Japan, and institutions encounter only a limited number of cases. This is one of the reasons for the current skepticism in Japan over whether hepatocellular adenoma can truly undergo malignant transformation to hepatocellular carcinoma. However, hepatocellular adenoma is highly prevalent in Western countries, particularly in Europe, and textbooks...

Thyrotoxic Periodic Paralysis (TPP) is a rare manifestation of hyperthyroidism characterized by muscle weakness and hypokalemia. Thyroid-Stimulating Hormone (TSH)-secreting pituitary adenoma is a rare cause of hyperthyroidism. Even more rare is the occurrence of TPP as the first manifestation of a TSH-secreting pituitary adenoma. We report a 31-year-old Asian male patient suffering from TPP cau...

INTRODUCTION Pleomorphic adenoma accounts for 65 percent of all salivary gland tumors. It has been identified in several anatomical regions, but pleomorphic adenoma arising in the ear canal, first described in 1951, is extremely rare. CASE PRESENTATION A 40-year-old Japanese man's left ear canal was obstructed by a pleomorphic adenoma that caused mild conductive hearing loss. The tumor was re...

Middle ear adenoma is a rare disease that is thought to originate in the middle ear mucosa. It occurs over a wide age range, has no gender predilection, and is not characterized by specific symptoms or findings. The most frequent complaints are unilateral hearing loss and ear fullness. We report a 48-year-old woman with middle ear adenoma who had a history of unilateral ear fullness and hearing...

BACKGROUND Pituitary adenoma is a common intracranial tumor in neurosurgery. Some pituitary adenomas have the characteristics of invasive growth make them unable to be removed completely by surgery leading to easy relapse. Discoidin domain receptor l (DDR1) is a new kind of tyrosine kinase receptor on the cell surface. DDR1 can be activated by tumor microenvironment signal in tumorigenesis, inc...

Background: Carcinoma ex pleomorphic adenoma is an exceedingly rare neoplasm of the submandibular gland with an overall poor prognosis. Metastatic deposits of carcinoma ex pleomorphic adenoma are either composed exclusively of malignant elements or contain mixed benign and malignant components. Case Presentation: We describe the case of a 63-year-old male with a carcinoma ex pleomorphic adenoma...

Hypokalemia may be present in some patients with Sjogren's syndrome. When a patient syndrome presents hypokalemia, we would first consider it to result of the renal involvement However, this case report, young woman who presented hypokalemia that was not caused by tubular acidosis but presence coexisting aldosterone-producing adenoma. Cases adenoma are extremely rare. This finding underscores n...

BACKGROUND Colorectal adenoma is a precursor lesion of colorectal cancer and thus, it is an important target for preventing colorectal cancer. Only a few studies suggest an association between colorectal adenoma and obesity, but results show considerable heterogeneity. In this study, we investigated the association between colorectal adenoma and waist circumference. METHODS 165 adenoma cases ...

BACKGROUND It has been reported that the expression of the inhibitor of apoptosis protein (IAP) family increases in patients with colon cancer. We evaluated the expression of the IAP family and human telomerase reverse transcriptase (hTERT) in normal colon mucosa from patients with advanced colorectal adenoma and investigated their features according to characteristics of advanced colorectal ad...