Degradable and injectable hydrogels may be ideal for bone-tissue engineering, especially in the craniofacial region because of the ease of access for injection. Alginate hydrogels potentially could be used as injectable cell delivery vehicles, but they exhibit a limited range of mechanical properties and uncontrollable disintegration time. Therefore we synthesized new hydrogels, composed of pol...

Mutations in an enzyme can result in a neomorphic catalytic activity in cancers. We applied cancer-associated mutations from isocitrate dehydrogenases to homologous residues in the active sites of homoisocitrate dehydrogenases to derive enzymes that catalyze the conversion of 2-oxoadipate to (R)-2-hydroxyadipate, a critical step for adipic acid production. Thus, we provide a prototypic example ...

The green biosynthesis of adipic acid, an important monomer nylon 6,6, has become a research hotspot. α-Aminoadipate is key intermediate in the metabolic pathway that converts L-lysine to produce acid. In addition, flux analysis part engineering. Many optimization algorithms have been developed predict engineering intervention strategies with aim improving production target chemicals. Here, Opt...

This paper will introduce dihydrazides, a relatively obscure class of curing agents useful in virtually all thermoset resin systems. First described in 1958, by Wear, et al. dihydrazides are useful curing agents for epoxy resins, chain extenders for polyurethanes, and excellent crosslinking agents for acrylics. In one-part epoxy systems, depending on the backbone chain of the chosen dihydrazide...