BACKGROUND Adipocytes are hormonally active molecules modulating biochemical processes on-going in human organism. Visceral fat tissue is the source of many important substances, such as: adiponectin, TNF-α, resistin and many others. However, their role has not been fully elucidated. AIM 1. To measure the concentrations of adiponectin, soluble receptors for TNF-α, and resistin in patients wit...

BACKGROUND The incidence of obesity has risen dramatically over the last few decades. This epidemic may be affected by exposure to xenobiotic chemicals. Bisphenol A (BPA), an endocrine disruptor, is detectable at nanomolar levels in human serum worldwide. Adiponectin is an adipocyte-specific hormone that increases insulin sensitivity and reduces tissue inflammation. Thus, any factor that suppre...

Іntroduction. Today, a quarter of the population economically developed countries has body weight that is 15% larger than norm. According to various authors, timely onset menarche in women with forms obesity and reproductive dysfunction observed 31% cases only.
 Obesity results insulin resistance, which its turn hyperinsulinemia. The main reason connection resistance function disorders con...

AdipoR1 and AdipoR2 are newly discovered members of the huge family of seven-transmembrane receptors, but both receptors are structurally and functionally different from G-protein-coupled receptors. Little is known about the oligomerization of the AdipoRs. Here, we show the presence of endogenous AdipoR1 dimers in various cell lines and human muscle tissue. To directly follow and localize the d...

Adiponectin is an adipose-secreted hormone that regulates energy homeostasis and is also involved in the control of the reproductive system. The goal of the present study was to investigate changes in adiponectin gene and protein expression in porcine ovarian structures during the oestrous cycle and to examine the effects of in vitro administration of adiponectin on basal and gonadotrophin- and...

CONTEXT Adiponectin, an adipocyte-secreted hormone, is associated with insulin resistance and the metabolic syndrome. OBJECTIVE The physiological regulation of circulating adiponectin levels and mRNA expression of its receptors (AdipoR1 and AdipoR2) in skeletal muscle remains to be fully elucidated. DESIGN/PATIENTS We assessed circulating adiponectin and AdipoR1/R2 mRNA expression in human ...

Adipose tissue in abdominal obesity produces various cytokines, the most important of which is adiponectin (AN). Polymorphism AN receptor genes associated with risk metabolic syndrome (MS) and type 2 diabetes mellitus (DM2) development. The aim study was to investigate association receptors’ polymorphism development MS DM2 Republic Crimea as well possibility named pathology correction polypheno...