The premise that breast cancer (BC) has a tendency toward early systemic dissemination, together with empirical findings showing that drugs given after breast tumor surgery improve outcome, led to the development of systemic adjuvant therapy. This strategy, which started more than 50 years ago, revolutionized BC treatment and improved patient outcome in a substantial way. However, in recent yea...

Adjuvant Chemotherapy in Primary Breast Cancer Adjuvant chemotherapy reduces the relative risk of relapse by about 25% – independent of the nodal status. Anthracycline-containing regimens are considered standard for adjuvant chemotherapy. In single studies, superiority to CMF has only been shown for anthracyclinecontaining polychemotherapies with at least three substances or a sequential anthra...

BACKGROUND & AIMS A significant benefit of imatinib adjuvant therapy for patients with high risk gastrointestinal stromal tumors (GIST) has been confirmed. However, the effect of imatinib adjuvant therapy for intermediate-risk GIST has not been well studied. In this article, we compare differences of recurrence-free survival (RFS) rates between patients with intermediate-risk GIST who accepted ...

Adjuvant therapy for pancreatic cancer remains controversial. However, both sides of the Atlantic Ocean agree that at least gemcitabine should be the pivotal agent offered to all patients. The role of radiation therapy remains somewhat inconclusive but chemoradiation, whether in the neoadjuvant or adjuvant setting is a standard option often utilized in the USA. This review is an update from the...

Endometrial cancer is a common gynecologic malignancy typically diagnosed at early stage and cured with surgery alone. Adjuvant therapy is tailored according to the risk of recurrence, estimated based on the International Federation of Gynecology and Obstetrics (FIGO) stage and other histological factors. The objective of this manuscript is to review the evidence guiding adjuvant therapy for ea...

Most patients diagnosed with localized prostate cancer today are cured with surgery or radiation therapy to the prostate. However, a subset of patients can be defined as having a high risk of failure with standard treatment. This risk stratification for disease recurrence is based on established parameters for T stage, Gleason score and PSA. Adjuvant therapy after surgery has been applied in ot...

Background: The impact of NACT on immediate breast reconstruction outcomes remains unclear. We assessed the effect neoadjuvant chemotherapy (NACT) post-operative complications and delay to adjuvant therapy among women undergoing reconstructions.

The majority of patients with operable esophageal cancers present with locally advanced disease, for which surgical resection as a sole treatment modality has been historically associated with poor survival. Even following radical resection, most of these patients will eventually succumb to their disease due to distant metastasis. For this reason, there has been intense interest in the role of ...