Invariably in every normal rat a single dose of 7, 12-dimethylbenz(a)anthracene, by mouth or injected in a vein, was found to cause apoplexy and massive necrosis in the inner zones of the adrenal cortex; the zona glomerulosa, the adrenal medulla, and a small region of cortex adjacent to the great adrenal vessels were spared from damage. DMBA caused these selective lesions in females and in male...

Werner syndrome is a rare genetic disease characterized by progeria, diabetes mellitus, cataracts and various types of malignancy. However, there are few reports showing adrenal cortex cancer in subjects with Werner syndrome. We herein report an extremely rare case of Werner syndrome accompanied by adrenal cortex cancer. Based on the data obtained from blood samples, computed tomography, magnet...

Hedberg Alm, Y. 2006. Oestrus in the mare with emphasis on deviant behaviour and adrenal gland function. Some owners appear to experience problems with their mares due to excessive oestrous signs and/or changes in their mare's behavioural characteristics across the oestrous cycle. Few such mares are examined at equine clinics and, thus, the cause of such behaviour is often unknown. Adrenal sex ...

OBJECTIVES Giant cell arteritis (GCA) is a chronic systemic vasculitis of large and medium-sized arteries, for which long-term glucocorticoid (GC) treatment is needed. During GC withdrawal patients can suffer adrenal insufficiency. We sought to determine the time until recovery of adrenal function after long-term GC therapy, and to assess the prevalence and predictors for secondary adrenal insu...

INTRODUCTION Diabetes is one of the most common endocrine disorders characterized by hyperglycemia due to defects in insulin secretion, insulin function, or both. Causing dysfunction in the body general metabolism, diabetes-induced chronic hyperglycemia leads to alterations in those endocrine glands involved in regulating the body metabolism. In this line, the present study has been conducted t...

Abstract Background: Established medical practice is that adrenalectomized patients require lifelong steroid replacement. We report a case which challenges assumption. Clinical Case: A 38 year old female underwent transsphenoidal resection of proven ACTH secreting pituitary adenoma. Post operatively her function was preserved, but due to residual tumour activity and the desire preserve fertilit...

The adrenal glands were first described in 1552 by the Italian anatomist Bartolomeo Eustachi in his Opuscula Anatomica as ‘‘glandulae renis incumbentes’’ (glands lying on the kidney) [1], but their function remained controversial for the next 300 years [2]. The adrenal have a dual origin (Fig. 2.1a, b), i.e. the cortex arises from mesoderm whereas the medulla has a neuroectodermal origin [2]. T...

Numerous investigators have reported that anoxia produces an activation of the adrenal medulla,4' 10, 11, 16, 25, 40, 41, 50, 57 but only recently has it been revealed that the adrenal cortex is also activated when an animal is exposed to low atmospheric pressure. Evans reported17' 18 in 1934 and 1935 a striking increase in blood sugar and liver glycogen in rats exposed to one-half atmospheric ...

In a previous paper (Robson and Kilborn, 1965) we described some observations on adrenocortical function in continuous asthma. The methods employed were the cortisol production rate using an isotope dilution method (De Witt, Robson, and Stewart, 1962) and the specific measurement of plasma cortisol during adrenocorticotrophic hormone (A.C.T.H.) stimulation by a continuous intravenous infusion (...

OBJECTIVE: To evaluate and compare the degree of adrenal cortex suppression in patients receiving long term treatment with different formulas and doses of glucocorticoids (GC) which is of considerable diagnostic and therapeutic importance. METHODS: A total of 97 subjects (51 women and 46 men) with bronchial asthma was divided into the groups subjected to different GC treatment (e.g. inhalation,...