Emotional stress activates the sympathetic nervous system (SNS) and release of the neurotransmitter norepinephrine to promote breast tumor pathogenesis. We demonstrate here that themetastatic mammary adenocarcinoma cell line 4T1 does not express functional adrenergic receptors (AR), the receptors activated by norepinephrine, yet stimulation of adrenergic receptor in vivo altered 4T1 tumor progr...

Purpose. To identify agonists that elevate cytosolic Ca (Cap) in lens cells and to characterize their mechanism of action. Methods. Digital imaging and the Ca-reporting dye fura-2 were used to study the effects of agonists and their antagonists on Caf in sheep lens primary cell cultures. Results. Exposing cells to adenosine triphosphate (ATP) and epinephrine increased Caf, whereas dopamine, 5-h...

The highly specific a -adrenergic agonist, dexmedetomidine, has hypnotic-sedative, anesthetic-sparing and analgesic effects, and it 2 protects neurons against ischemia. The a -adrenergic agonist, phenylephrine, does not share dexmedetomidine’s pharmacological 1 21 21 properties, although both dexmedetomidine and phenylephrine increase free cytosolic Ca ([Ca ] ) in astrocytes, and most of i dexm...

Secretory vesicle swelling is required for vesicular discharge during cell secretion. The G(αo) -mediated water channel aquaporin-6 (AQP-6) involvement in synaptic vesicle (SV) swelling in neurons has previously been reported. Studies demonstrate that in the presence of guanosine triphosphate (GTP), mastoparan, an amphiphilic tetradecapeptide from wasp venom, activates G(o) protein GTPase, and ...

1. We investigated the effect of adrenergic receptor stimulation or inhibition on the hepatic ultrastructural changes in a porcine faecal peritonitis model of multi-organ failure. We infused either the α1 adrenergic receptor agonist methoxamine or the β2 adrenergic receptor antagonist ICI 118551 during 8 h of the study. 2. Anaesthetized pigs (25–30 kg) were divided into four non-septic groups (...

The coronary arteries receive rich adrenergic innervation. The present study examines the effects of changes in adrenergic activity on the coronary circulation without the complicating influence of autoregulation. Diastolic and mean circumflex coronary artery pressure-flow relations were generated in conscious dogs and were described by their slope and zero-flow, pressure-axis intercept during ...

Salsolinol, an endogenous neurotoxin, is known to be involved in the neuropathy of Parkinson's disease and chronic alcoholism. In these diseases, increased thrombotic events are also commonly reported, yet the mechanism underlying remains poorly understood. Here we report that salsolinol can enhance agonist-induced platelet aggregation and granular secretion, which is essential in the thrombus ...

Sympathetic nerves may play a role in vascular disorders of the eye. In the present study, we hypothesized that activation of 3-adrenergic receptors on retinal endothelial cells would promote migration and proliferation of these cells, two markers of an angiogenic phenotype. We show, for the first time, expression of 3adrenergic receptors on cultured retinal endothelial cells. Activation of the...

The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is occupied by stimulatory agonists. Since this kinase may play an important role in mediating the process of homologous, or agonist-specific, desensitization, we investigated the functional consequences of receptor phosphorylation by t...

BACKGROUND In this work, effect of Tamsulosin hydrochloride as antagonist of alpha1A and alpha1B- adrenergic receptor and effect of Salbutamol as agonist of beta2- adrenergic receptor in patients with bronchial asthma and increased bronchial reactibility was studied. METHODS Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and specific resis...