The two branches of the autonomic nervous system (ANS), adrenergic and cholinergic, exert a multitude effects on human myocardium thanks to activation distinct G protein-coupled receptors (GPCRs) expressed plasma membranes cardiac myocytes, fibroblasts, coronary vascular endothelial cells. Norepinephrine (NE)/epinephrine (Epi) acetylcholine (ACh) are released from ANS terminals mediate biologic...

Formyl peptide receptor-induced chemotaxis of neutrophils depends on the release of ATP and autocrine feedback through purinergic receptors. Here, we show that adrenergic receptor signaling requires similar purinergic feedback mechanisms. Real-time RT-PCR analysis revealed that human embryonic kidney (HEK)-293 cells express several subtypes of adrenergic (α(1)-, α(2)-, and β-receptors), adenosi...

Tocolytic therapy with beta-adrenergic receptor agonists is a standard regimen to prevent preterm birth. Agonists exposure of beta-adrenergic receptors causes receptor desensitization in other organs, and this may limit the therapeutic value of beta-adrenergic receptor agonists. To study the effects of prolonged beta-adrenergic agonist treatment in human myometrium, we obtained biopsies during ...

KONDO, S., KAGAYA, M., TASHIMA, Y. and MORITA, T. The Quantitative Difference in Adrenergic Alpha-1, Alpha-2 and Beta Receptors between the Prostatic and Epididymal Ends of Dog Vas Deferens. Tohoku J. Exp. Med., 1992, 167 (2), 167-169 In order to study the regional differences in the distribution of adrenergic receptors of the vas deferens, we measured the amounts of adrenergic a-1, a-2 and R r...

6,and b2-adrenergic receptors, pharmacologically distinct proteins, have been reported to be structurally dissimilar. In the present study three techniques were employed to compare the nature of mammalian &and Bz-adrenergic receptors. Antibodies against each of the receptor subtypes were raised separately. Polyclonal antisera against &-receptors f rat fat cells were raised in mice, and antisera...

The prokinetic effect of metoclopramide is mediated through the blockade of enteric (neuronal and muscular) inhibitory dopamine D2 receptors, and metoclopramide has the ability to stimulate 5-HT3 and 5-HT4 receptors (2). Metoclopramide also exerts inhibitory effects on D2 receptors centrally (located outside the blood-brain barrier), and these contribute to its antiemetic effect. Metoclopramide...

ion fluxes in these cells, we have now examined the possibility that the decrease in beta receptor number might be associated with concomitant changes in catecholamine-dependent potassium ion transport. Hypothyroid turkey erythrocytes display decreased sensitivity to isoproterenol-stimulated potassium influx. Half-maximal stimulation of potassium influx occurs at 9.2±+1.7 nM in hypothyroid cell...

Objective - to study, the dynamics of catecholamine binding on erythrocytes when modeling stimulation and blockade adrenergic regulation mechanisms using cytological method
 Material methods. The number granules was determined silver nitrate impregnation under conditions administration anapriline -adrenergic receptor blocker (2 mg/kg), acute stress, activation noradrenergic systems (maprot...

Previous studies performed with crude homogenates have demonstrated the presence of beta-adrenergic receptors in the rat ventral prostate. The precise localization of these receptors in prostatic tissue, however, has not been determined. The present study describes the localization of beta-adrenergic receptors using in vitro radioautography. beta-adrenergic receptors are present exclusively in ...

Different classes of receptors mediate norepinephrine and epinephrine effects, one of the most recently discovered being the beta 3 adrenergic ones. The paper has proposed itself to present the history of the discovery of beta 3 adrenergic receptors, different techniques for their identification, their structure, localization, genetic data and also the mechanism of regulation of their functions...