Adverse drug events (ADEs) have been recognized as a significant healthcare problem worldwide. Prior studies have shown that health social media can be used to generate medical hypotheses and identify adverse drug events. Most studies adopted supervised learning approach for ADE detection in health social media, which requires human annotated data and is not scalable to large datasets. In this ...

OBJECTIVE To quantify the frequency and seriousness of adverse events in non-oncology phase I studies with healthy participants. DESIGN Meta-analysis of individual, healthy volunteer level data. SETTING Phase I studies with healthy volunteers conducted between September 2004 and March 2011 at Pfizer's three dedicated phase I testing sites in Belgium, Singapore, and the United States. These ...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: pharmacovigilance assesses the safety profile of drugs. its main aim is the increase of spontaneous reporting of adverse drug reactions (adrs).the italian drug agency (aifa; agenzia italianadel farmaco) is financing several projects to the aim of increasing reporting, and in calabria a pharmacovigilance informa...

OBJECTIVES Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD A cross-sectional study was performed in ...