Ibuprofen was the first member of Propionic acid derivatives introduced in 1969. It is a popular domestic and over the counter analgesic and antipyretic for adults and children. Ibuprofen has been rated as the safest conventional NSAID by spontaneous adverse drug reaction reporting systems in the UK. This article summarizes the main pharmacological effects, therapeutical applications and advers...

BACKGROUND Decisions on treatment are guided, not only by the potential for benefit, but also by the nature and severity of adverse drug reactions. However, some researchers have found numerous deficiencies in trial reports of adverse effects. We sought to confirm these findings by evaluating trials of drug therapy published in seven eminent medical journals in 1997. METHODS Literature review...

IntRoductIon An adverse drug reaction (ADR) is unintended injuries caused by the drug at normal doses during normal use.[1] ADR monitoring is a long‐term work of medical institutions. Medical institutions at all levels have their corresponding requirements of reporting ADRs.[1] On December 12, 2010, the National Health and Family Planning Commission of the People’s Republic of China issued the ...

Spontaneous adverse drug reaction (ADR) reporting is the cornerstone of pharmacovigilance. However, underreporting is a huge problem due to lack of reporting culture amongst healthcare professionals. This cross sectional, questionnaire based study was conducted to assess the knowledge, attitudes and practices regarding adverse drug reaction reporting amongst resident (trainee) doctors. It invol...

In India, the pharmacovigilance program is still in its infancy. National Pharmacovigilance Program of India was started for facilitating the pharmacovigilance activities. The ADR reporting rate is still below satisfactory in India. This cross-sectional questionnaire based study was carried out in a tertiary care teaching hospital in Uttarakhand, which is a peripheral ADR monitoring centre to a...

OBJECTIVE We analyzed differences between spontaneously reported drug-induced (not including contrast media) and contrast media-induced adverse reactions. METHODS Adverse drug reactions reported by an in-hospital pharmacovigilance center (St. Mary's teaching hospital, Daejeon, Korea) from 2010-2012 were classified as drug-induced or contrast media-induced. Clinical patterns, frequency, causal...