Sorafenib is a multikinase inhibitor thought to target vascular endothelial growth factor and its receptor. The European Medicines Agency (EAMA) and Food and Drug Administration (FDA) approved the use of sorafenib in late-stage hepatic cellular cancer (HCC) on October 30, 2007, and November 19, 2007, respectively. It is the only drug approved for use in the systematic treatment of primary HCC, ...

Penicillin is the drug that most often leads to allergic reactions and anaphylaxis. The incidence of adverse events triggered by penicillins is believed to be between 1% and 10%. Up to one-tenth of these episodes are life-threatening, with the most serious reactions occurring in patients with no history of allergy. The case of a 5 year, 3 month-old female who had a severe allergic reaction to a...

A 57-year-old man was admitted to our hospital for evaluation and management of stroke in the setting of an atrial septal defect. Shortly after receiving gadobenate dimeglumine for magnetic resonance imaging of the pelvic vessels, he experienced cardiac arrest from which he was resuscitated. His course was complicated by profound distributive shock. The presumed cause was a severe anaphylactic ...

In the evaluation of patients with a history of adverse cutaneous drug reactions, it is important to obtain a detailed medication therapy including over-the-counter drugs, herbal and neuropathic remedies. There are a significant number of offending drugs causing adverse cutaneous drug reactions. If we can find out the clinical pattern of drug reaction along with their risk and aggravating facto...

LABOR FÜR KLINISCHE DIAGNOSTIK GMBH & CO.KG Info 02/2007 Seite 1 Steubenstraße 4 • 97688 Bad Kissingen • Telefon: 0971/72020 • Fax: 0971/68546 • www. laboklin.com The small intestine (SI) mucosa has a general barrier function but must also be protective. Thereby an immune response against pathogens takes place while harmless environmental antigens (bacteria, food components) must be tolerated. ...