The presence of fungi and aflatoxin B1 (AFB1) in 101 animal feed samples randomly collected from different vendors factories Algeria was investigated. For fungi, the main genera isolated were Aspergillus, Penicillium Fusarium. Furthermore, 459 strains Aspergillus section Flavi screened for their ability to produce aflatoxins cyclopiazonic acid (CPA). 49% produced AFB1 while 74.5% producers. hig...

Aflatoxin is a natural potent carcinogen and a major cause of liver cancer. However, the molecular mechanisms of hepatocellular carcinogenesis remain largely unexplored. In this study, we profiled global gene expression in liver tissues of rats that developed hepatocellular carcinoma (HCC) from aflatoxin B1 (AFB1) administration and those that were AFB1-resistant, as well as rats without AFB1 e...

Feed safety becoming the main factor to produce good quality food. The purpose of this study was evaluate ability lactic acid bacteria in degrading aflatoxin B1, suppressing growth contaminant bacteria, and its application on feed. Biological degradation B1 (AFB1) liquid cultures Escherichia coli Saccharomyces aureus inhibition by Lactobacillus plantarum were examined. Fermentation corn for 24 ...

The purpose of the study was to evaluate short-term effects aflatoxin B1 (AFB1 100 µg/kg feed) and sterigmatocystin (STC 1000 μg/kg exposure individually in combination (100 μg AFB1 + STC/kg on parameters lipid peroxidation glutathione redox system both biochemical gene expression levels one-year-old common carp. Lipid were slightly affected, as significant differences observed only conjugated ...

Routine dietary consumption of foods that contain aflatoxins is the second leading cause of environmental carcinogenesis worldwide. Aflatoxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B1 (AFB1) to its epoxide form that reacts with N7 guanine in DNA. The resulting AFB1-N7-dG adduct undergoes either spontaneous depurination or imidazole-ring opening yielding formam...

Indole-3-carbinol (I3C) was examined for its ability to inhibit aflatoxin B1 (AFB1)-induced hepatocarcinogenesis in male Fischer rats when administered either before or after the carcinogen. After 13 weeks, animals pretreated with I3C (0.5% in the diet) for 2 weeks prior to administration of AFB1 and with continuing treatment during exposure to the carcinogen were protected from development of ...

Aflatoxin B1 (AFB1) is a highly toxic substance produced mainly by Aspergillus spp., which are known to contaminate wide variety of foods and feeds. The objective this study was understand the growth AFB1 production rate flavus NRRL 3357 investigate impact different infrared (IR) heat intensities on aflatoxin-producing potential A. flavus. Thirty healthy corn kernels were inoculated with 1 × 10...

Mycotoxin is a worldwide problem threatening animal health and performance as well public health. The objective of this experiment was to test the effect ammonization on elimination common mycotoxins in laying hen compound feed (CF) dairy cattle total mixed ration (TMR). CF for hens TMR cows were contaminated with commonly occurring [aflatoxin B1 (AFB1), ochratoxin A (OTA), zearalenone (ZEA)] a...

Aflatoxin B1(AFB1) and total Aflatoxins (AFT) contaminated feed effect on aflatoxins residue level in eggs, muscles (breast, leg), organs (liver, kidney, gizzard) and excreted aflatoxins in chicken litter of layer hens were monitored. Laying hens were on four levels of aflatoxins for 6 weeks and monitored weekly for the change in both AFB1 and AFT levels. Pronouncedly, the AFB1 and AFT were det...

Background: Activation of inflammatory cells can cause more chemicals induced-hepatotoxicity. Aflatoxin B1 (AFB1) is a fungal toxin that induces acute hepatotoxicity in humans and animals. This study was conducted to examine the effect of co-exposure LPS and various aflatoxin B1 doses on the damage hepatic parameters in isolated perfused rat liver. Methods: Thirty-two male wistar rats (250-3...