Debio 1452, formerly called AFN-1252 (Fig. 1), is an investigational FabI inhibitor that has demonstrated potent activity against Staphylococcus aureus (1–5). Currently, Debio 1450 (prodrug of Debio 1452) is in clinical development by the Debiopharm Group (6, 7). Debio 1452 selectively inhibits bacterial enoyl-acyl carrier protein (enoyl-ACP) reductase, an essential step in the elongation cycle...

The Fibonacci sequence F = 0, 1, 1, 2, 3, 5, 8, . . . has intrigued mathematicians for centuries, as it seems there is no end to its many surprising properties. Of particular interest to us are its properties when reduced under a modulus. It is well known, for example, that F (mod m) is periodic, that the zeros are equally spaced, and that each period of F (mod m) contains exactly 1, 2, or 4 ze...

We study the structure of length three polynomial automorphisms of R[X, Y ] when R is a UFD. These results are used to prove that if SLm(R[X1, X2, . . . , Xn]) = Em(R[X1, X2, . . . , Xn]) for all n,≥ 0 and for all m ≥ 3 then all length three polynomial automorphisms of R[X, Y ] are stably tame. 1. Introducton Unless otherwise specified R will be a commutative ring with 1 and R = R[X ] = R[X1, ....

In 2014, John Loxley was called as an expert witness for the plaintiffs in a legal case filed 2007 by First Nations Child and Family Caring Society (Caring Society) Assembly of (AFN) against Government Canada. The alleged that Canadian government's choice to underfund child welfare other children's services on reserves Yukon amounted racial discrimination. Loxley's expertise, context, derived f...

The standard scenario for GPS surveying is to use two carrier phase-tracking GPS receivers, one located at a "reference" station with known coordinates and the second one at a station whose coordinates are to be determined. (It is also possible to determine a trajectory when the second receiver is in motion.) However, the cost of two GPS receivers, and associated software, is high and has precl...