نتایج جستجو برای: age 2433 141
تعداد نتایج: 766124 فیلتر نتایج به سال:
OBJECTIVE Store operated calcium channels (SOCCs) and Receptor-operated calcium channels (ROCCs) are important pathways participating in regulation of intracellular Ca(2 +) concentration in various cell types. The purpose of our study is to determine whether genetic variations in key components of SOCCs and ROCCs are associated with lung cancer risk. METHODS We identified 236 tagSNPs in 9 key...
BACKGROUND Fetal growth restriction (FGR) is an important but poorly understood condition of pregnancy, which results in significant fetal, neonatal and long-term morbidity and mortality. Novel research has suggested that altered miRNA expression in the plasma and placenta is associated with adverse pregnancy. We hypothesized that aberrant expression of microRNA-141 (miR-141) in the placenta is...
To understand why livers from aged donors are successfully used for transplants, we looked for markers of liver aging in 71 biopsies from donors aged 12-92 years before transplants and in 11 biopsies after transplants with high donor-recipient age-mismatch. We also assessed liver function in 36 age-mismatched recipients. The major findings were the following: (i) miR-31-5p, miR-141-3p, and miR-...
The microRNA, miR-141, is a promising biomarker for prostate cancer. We implement here a two-step sensing platform for the sensitive detection of miR-141. The first step involves the use of semiconductor CdSe/ZnS quantum dots (QDs) modified by FRET quencher-functionalized nucleic acids, that include the recognition sequence for miR-141 and a telomerase primer sequence for the second step of the...
The concept of ventricular septal defect as a disease of little severity (Roger, 1879; Brown, 1950), has been upset by the observations of Marquis (1950) and Engle (1954). The median age at death in Abbott's (1951) cases was 141 years; however, in common with others, we have observed severe disability and death in many younger children. The advent of surgical therapy for this defect (Lillehei, ...
BACKGROUND Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. miR-141-3p is an extensively studied miRNA in cancers and downregulation of miR-141-3p has been widely reported to be involved in the progression and metastasis of several human cancer types. However, the clinical significance and biological roles of miR-141-3p in bone metastasis of PCa are still unclea...
BACKGROUND We have demonstrated that T lymphoma invasion and metastasis 1 (Tiam1) gene is associated with the poor prognosis of patients with hepatocellular carcinoma (HCC), and we used a computational approach to identify miR-141 as a Tiam1-targeting microRNA (miRNA). Here, we explored the function of miR-141 and the relationship between miR-141 and Tiam1 gene in HCC. METHODS The miR-141 exp...
Dysregulation of microRNAs (miRNAs) has been associated with the initiation and progression of oncogenesis in humans. Growing evidence has indicated that abnormal expression of microRNA-141 was associated with tumorigenesis and carcinoma progression of various cancers. In the present study, the miR-141 expression was assessed in CRC cell lines and the normal colonic cell using RTq-PCR, which de...
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