A case of sick sinus syndrome, which was originally diagnosed during 1958, had an extensive followup for over 20 years by several clinicians. He showed a wide spectrum of associated rhythm disorders includ-tng sinus irregularity, extrasystoles, paroxysmal supraventricular tachycardia and Wenkebach's phenomenon. He remained physically fit and active, and did not require active medications, and d...

Three germline mutations in the TP53 tumor-suppressor gene are reported, two of which are not reported previously. A missense mutation at codon 265 of TP53 was found in three patients of a family that complied with the definition of the Li-Fraumeni syndrome. A nonsense mutation in codon 306 was found in a woman who had had a rhabdomyosarcoma at age 4 and a subsequent breast cancer at age 22. Sh...

A high intake of fruit and vegetables (FV) is associated with reduced risk of chronic disease, although the evidence base is mostly observational. Blood biomarkers offer an objective indicator of FV intake, potentially improving estimates of intakes based on traditional methods. A valid biomarker of overall FV intake would be able to confirm population intakes, more precisely evaluate the assoc...

State’s 66,511 square miles is rural. In 1994, there were 1.6 million women aged 10–49 in the state, and 17% of them lived in rural areas.5 The state has a long history of legal access to abortion, but the number of providers in rural Washington State has always been limited and has declined further in recent years. In 1983, only 10 of the state’s 28 rural counties had a provider; there were 19...

223 words) .......................................................................................................... 2 INTRODUCTION (758 words) .................................................................................................. 3 A CRITICAL LITERATURE REVIEW (1867 words) .................................................................... 6 SUMMARY AND CONCLUSION (682 words) ......

Running title: Vascular interactions between ANP and NO Classification: Biological Sciences, Physiology Manuscript information: 21 pages, 6 figures; abstract with 245 words, 5151 words in total. Abbreviations footnote: ANP, atrial natriuretic peptide; CNP, C-type natriuretic peptide; NO, nitric oxide; GC-A, guanylyl cyclase-A; sGC, soluble guanylyl cyclase; PKG I, cGMPdependent Protein Kinase I...

introduction: in order to make a dimensional proportion between human and equipment or environment, anthropometric data bank is essential. anthropometry has an important role in industrial management and ergonomic design. this information is needed to be collected regularly in every society. the purpose of this study was to determine arm length to height ratio according to gender in adults, bet...

Bortezomib is a highly selective inhibitor of the 26S proteasome and has been approved for clinical use in the treatment of relapsing and refractory multiple myeloma and mantle cell lymphoma. Clinical trials are also underway to assess the role of bortezomib in several other human malignancies, including leukemia. However, the mechanism(s) by which bortezomib acts remain to be fully understood....