Dopamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [373]) are commonly divided into D1-like (D1 and D5) D2-like (D2, D3 D4) families, where endogenous agonist is dopamine.

Among aging-induced impairments, those affecting cognitive functions certainly represent one the most major challenge to face improve elderly quality of life. In last decades, our knowledge on changes in morphology and function neuronal networks associated with normal pathological brain aging has rapidly progressed, initiating development different pharmacological behavioural strategies allevia...

Rationale: The ? 2 -adrenoceptor (? -AR), a prototypical GPCR (G protein-coupled receptor), couples to both G s and i proteins. Stimulation of the -AR is beneficial humans animals with heart failure presumably because it activates downstream -PI3K-Akt cell survival pathway. Cardiac signaling can be regulated by crosstalk or heterodimerization other GPCRs, but physiological pathophysiological si...

OX40 is a costimulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. agonist-based combinations are emerging as promising candidates for novel cancer immunotherapy. Clinical trials have shown agonist antibodies could lead better results in patients. Using hybridoma platform and three different types of immunization strategies, namely recombinant protein, DNA, ...


 Platelets are essential elements of human blood. In addition to their normal role, platelets involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation vivo, probably involves a combination agonists. Garlic has beneficial effects due its ability inhibit platelet aggregation thromboxane formation. The aim this work was evaluate the garlic extract...

To investigate the channels and neurotransmitters in the ventrolateral medulla (VLM) oblongata that are responsible for the maintenance of sympathetic tone and cardio-respiratory reflex regulation. Microinjections of excitant amino acid (glutamate, 100 nl, 100 mM), calcium channel blockers, agonists and antagonists were made throughout the VLM in anaesthetized rats. Arterial blood pressure, sym...